This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Understanding the basic biology of cells will allow us to pinpoint key mechanisms and molecules that underpin multiple diseases and are targets for treatments. The broad aims of this research program include the development of new therapies for chronic inflammatory diseases, understanding how proteins are sorted and trafficked inside cells in processes that are essential to immunity and cancer biology, and identifying new intracellular targets to block bacterial invasion and infectious diseases.
Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel i ....Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel in-car interaction design implementations, provide important visual design guidelines for future display technologies, and provide novel road safety interventions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101542
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Risky Gadgets to the Rescue: Designing Personal Ubicomp Devices to Foster Safer Driving Behaviours in Young Males. Young males are over-represented in road crashes. Part of the problem is their proneness to boredom, a hardwired personality factor that can lead to risky driving or distractions. This project aims to design innovative ubiquitous computing technologies that make safe driving more stimulating and pleasurable. This research will inform the future design of personal ubiquitous devices ....Risky Gadgets to the Rescue: Designing Personal Ubicomp Devices to Foster Safer Driving Behaviours in Young Males. Young males are over-represented in road crashes. Part of the problem is their proneness to boredom, a hardwired personality factor that can lead to risky driving or distractions. This project aims to design innovative ubiquitous computing technologies that make safe driving more stimulating and pleasurable. This research will inform the future design of personal ubiquitous devices that pose a threat to road safety, by replacing the stimuli from risky driving with safer stimuli and simulating risk to increase risk perception when it is actually not present. This project aims to reduce risky driving behaviours, and, in the process, advance our knowledge about the role of boredom in the road safety context.Read moreRead less
Intention-aware cooperative driving behaviour model for Automated Vehicles. This project aims to investigate humans' cooperation with automated systems by conceptualising joint intention awareness. This project expects to generate knowledge about a new cooperative driving behaviour model for automated vehicles, utilising a transdisciplinary approach that mixes human-centric methods with deep learning techniques. Intended outcomes are new joint intention awareness theory, new interface for automa ....Intention-aware cooperative driving behaviour model for Automated Vehicles. This project aims to investigate humans' cooperation with automated systems by conceptualising joint intention awareness. This project expects to generate knowledge about a new cooperative driving behaviour model for automated vehicles, utilising a transdisciplinary approach that mixes human-centric methods with deep learning techniques. Intended outcomes are new joint intention awareness theory, new interface for automated vehicles, new methodology for cooperative behaviour research, and enhanced research capacity. The expected significant benefits are for automated systems to become more predictable, acceptable, readable and safer to use by everyday people.Read moreRead less
Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contr ....Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contributors through sensing and active sharing, as well as novel interaction and visualisation approaches to aid in the analysis of the resulting data. The project intends to benefit both the insurers and the insured by making non-traditional data sources available for risk assessment and prevention.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Developing and evaluating a theoretically grounded novice driver education program incorporating simulators. Australian young drivers are 13 per cent of the population but account for nearly a quarter of road deaths. This project aims to develop a research informed, theory-driven education intervention that includes a simulator component to improve their driving skills and attitudes. A process and outcome evaluation aims to assess the effectiveness of the training including the impact on how ind ....Developing and evaluating a theoretically grounded novice driver education program incorporating simulators. Australian young drivers are 13 per cent of the population but account for nearly a quarter of road deaths. This project aims to develop a research informed, theory-driven education intervention that includes a simulator component to improve their driving skills and attitudes. A process and outcome evaluation aims to assess the effectiveness of the training including the impact on how individuals learn to drive, changes in skill and attitudes as well as the influence on crashes and offences. It is intended that a second parallel study will adapt the intervention for Indigenous Australians and examine the effectiveness of this adaptation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101061
Funder
Australian Research Council
Funding Amount
$373,697.00
Summary
Personal safety in the city: design solutions for after dark. The research will provide insights into the potential for mobile technology to be designed to enhance personal safety in urban environments at night. It will do so by identifying individual personal harm reduction and safety strategies, and examining the opportunities to use technology to amplify these strategies.
Human interaction with context-aware computing systems. Context-aware systems can provide seamless support of IT applications in a variety of technologies and therefore can improve: (i) work performance and adoption of IT in many industries; and (ii) the quality of life through better support for health services, education, and everyday tasks. Currently proposed solutions for context-aware systems fail to deliver systems which are usable for non-IT professionals. The proposed project will show h ....Human interaction with context-aware computing systems. Context-aware systems can provide seamless support of IT applications in a variety of technologies and therefore can improve: (i) work performance and adoption of IT in many industries; and (ii) the quality of life through better support for health services, education, and everyday tasks. Currently proposed solutions for context-aware systems fail to deliver systems which are usable for non-IT professionals. The proposed project will show how to design context-aware systems that are usable and whose autonomic decisions can be trusted. Additional benefits include increased scientific competitiveness of Australia, strengthened collaboration with international research institutions, and high quality graduates (PhDs, Masters, Honours).Read moreRead less