Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between mar ....Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between marsupials and other mammals. The focus on reproduction and development will also provide invaluable knowledge to underpin efforts to conserve our endangered species and to control those that are overabundant.Read moreRead less
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less
Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the ....Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the most fundamental questions in the whole of biology: what is the basis for the primal distinction between sex and soma?Read moreRead less
CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
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Extrinsic Control of Mammalian Germ Cell Delineation. Australia is a leader in the recent exciting breakthroughs in reproduction and development, such as cloning and embryonic stem cell propagation, and understanding how germ cells are specified would help us understand the biology underlying specification and developmental potential of all cells. This research will continue to contribute to maintaining Australia's high reputation in advances in reproductive biology. In addition, a greater under ....Extrinsic Control of Mammalian Germ Cell Delineation. Australia is a leader in the recent exciting breakthroughs in reproduction and development, such as cloning and embryonic stem cell propagation, and understanding how germ cells are specified would help us understand the biology underlying specification and developmental potential of all cells. This research will continue to contribute to maintaining Australia's high reputation in advances in reproductive biology. In addition, a greater understanding of marsupial reproduction is a high priority for Australia in the 21st century, with its current unacceptably high rate of mammalian extinctions, for 'we cannot conserve until we comprehend' (Short, 1985).The results therefore are of great potential benefit to society.
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Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
A multidisciplinary research program to assess limiting factors and predict impacts of climate change for endangered Australian orchids. Climate change poses a significant threat to biodiversity. Australian sexually deceptive orchids are dependent on obligate and specialised interactions with pollinators and fungi. Consequently, they may face a high risk of extinction if climate change uncouples these interactions. Thus orchids provide an important bio-indicator of change. The tools and expertis ....A multidisciplinary research program to assess limiting factors and predict impacts of climate change for endangered Australian orchids. Climate change poses a significant threat to biodiversity. Australian sexually deceptive orchids are dependent on obligate and specialised interactions with pollinators and fungi. Consequently, they may face a high risk of extinction if climate change uncouples these interactions. Thus orchids provide an important bio-indicator of change. The tools and expertise developed will contribute directly to the conservation of endangered Australian orchids, and will take into account the risks of climate change. The project will contribute to the priority research goals of sustainable use of Australia's biodiversity as well as responding to climate change and variability. The project will also provide high quality, cross-disciplinary training.Read moreRead less
Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is eco ....Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is economically vital for the industry and the development of such expertise within Australia will ensure we are well placed to exploit future advances in agricultural improvements and provide the capacity to further generate novel biotechnological applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452650
Funder
Australian Research Council
Funding Amount
$696,005.00
Summary
South Australian Virtual Reality Centre (SAVRC). It is proposed to install a fully immersive three dimensional visualisation facility in Adelaide, at a cost of $5.3 million including requested ARC contribution of $696,005. Applicant Institutions (Adelaide, Flinders, UniSA and Curtin universities) and Industry will provide the remainder.
The facility will support South Australia's leading scientific researchers in the sciences, engineering, business management, carbon dioxide sequestration, p ....South Australian Virtual Reality Centre (SAVRC). It is proposed to install a fully immersive three dimensional visualisation facility in Adelaide, at a cost of $5.3 million including requested ARC contribution of $696,005. Applicant Institutions (Adelaide, Flinders, UniSA and Curtin universities) and Industry will provide the remainder.
The facility will support South Australia's leading scientific researchers in the sciences, engineering, business management, carbon dioxide sequestration, petroleum exploration and production, space environment, bioinformatics, architecture, surgery, dentistry, archaeology and arts.
The facility will enable researchers and industry to significantly leverage other projects leading to much improved research outcomes and efficiency, potentially worth a hundred million dollars or more.
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