eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In ....eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In two parallel model systems we will study corals and reptiles to improve environmental detection while simultaneously obtaining information on their population health. This will foster more efficient conservation of endangered species that are of tremendous importance to our marine and terrestrial ecosystems.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Dispersal and persistence of large-seeded forest species under global environmental change. This project investigates how decline of a key seed disperser, the emu, due to global environmental change (fragmentation, fire regime change, human population growth, climate change) affects the persistence and migration potential of endemic SW Australian forest plant species. Results will inform approaches to ecosystem management and conservation
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Is restoration working? An ecological genetic assessment. This project aims to assess the success of restoration in terms of ecological and genetic viability for plant species in the Fitzgerald River–Stirling Range region of Western Australia, where significant investment is being made in restoring connectivity at a landscape scale. The project intends to compare reproductive output, pollinator behaviour, mating, genetic diversity and pollen dispersal in restored sites with those of undisturbed ....Is restoration working? An ecological genetic assessment. This project aims to assess the success of restoration in terms of ecological and genetic viability for plant species in the Fitzgerald River–Stirling Range region of Western Australia, where significant investment is being made in restoring connectivity at a landscape scale. The project intends to compare reproductive output, pollinator behaviour, mating, genetic diversity and pollen dispersal in restored sites with those of undisturbed natural vegetation. The project moves measures of restoration success beyond that of population establishment and survival to incorporate the evolutionary processes that provide long-term resilience, persistence and functional integration of restored populations into broader landscapes.Read moreRead less
Establishment of the Australian Cane Toad Genome Program. The Cane Toad is one of Australia's greatest environmental menaces, and is in the top 100 of the "World's Worst invader species". Over a billion toads infest Northern Australia, and they will soon invade WA and move further into NSW. Their poisons and voracious appetite could make many native mammals, birds and reptiles extinct. The only possibility to eradicate the Toad is by biological control, but there is no known control agent. We wi ....Establishment of the Australian Cane Toad Genome Program. The Cane Toad is one of Australia's greatest environmental menaces, and is in the top 100 of the "World's Worst invader species". Over a billion toads infest Northern Australia, and they will soon invade WA and move further into NSW. Their poisons and voracious appetite could make many native mammals, birds and reptiles extinct. The only possibility to eradicate the Toad is by biological control, but there is no known control agent. We will identify the 'Toad's Achilles' heel' against which control agents can be developed. We can do this by identifying every Toad gene. This project forms the first step to this goal by establishing the Australian Cane Toad Genome Program. Toad control will help preserve Australia's unique natural heritage.Read moreRead less
Population Genetics of Fungal Pathogens that Threaten the Biosecurity of Australia's Eucalypts. Many new pathogens and diseases are emerging on exotic eucalypt plantations throughout the world. These emerging diseases pose a threat to native eucalypt forests and plantations in Australia. Vigilant quarantine measures are necessary to prevent the introduction of potentially devastating pathogens into Australia. However, incursions do occur and there is a great need to study these pathogens now, ....Population Genetics of Fungal Pathogens that Threaten the Biosecurity of Australia's Eucalypts. Many new pathogens and diseases are emerging on exotic eucalypt plantations throughout the world. These emerging diseases pose a threat to native eucalypt forests and plantations in Australia. Vigilant quarantine measures are necessary to prevent the introduction of potentially devastating pathogens into Australia. However, incursions do occur and there is a great need to study these pathogens now, before they enter Australia. By studying the population genetics of pathogens, their evolutionary potential can be estimated and with that the extent of the risk they pose to native and planted eucalypts in Australia can be determined.Read moreRead less
Do hotter and drier regions harbour adaptive variation for climate change? This project aims to improve our understanding of the capacity of trees to respond to climate change. This is essential for the maintenance of biodiversity, forest health and productivity. In south-west Australia, climate variation has increased the frequency and intensity of droughts, which has resulted in tree death and negatively affected essential ecosystem services. Adaptive land management is urgently needed to miti ....Do hotter and drier regions harbour adaptive variation for climate change? This project aims to improve our understanding of the capacity of trees to respond to climate change. This is essential for the maintenance of biodiversity, forest health and productivity. In south-west Australia, climate variation has increased the frequency and intensity of droughts, which has resulted in tree death and negatively affected essential ecosystem services. Adaptive land management is urgently needed to mitigate the risk of large-scale drought mortality in a rapidly changing climate. This project seeks to deliver a scientific basis for the adoption of assisted gene migration in south-west forests, through a detailed understanding of genetic adaptation and physiological tolerance, to improve drought-resilience under future hotter and drier climates.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding o ....Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding of global human genomic variants and provide a range of new targets relevant to medical biology, while significantly improving our knowledge of human genetic history and its consequences in the modern day.Read moreRead less