A Case-control Study Of Rotavirus Vaccine Effectiveness Against Gastroenteritis Hospitalisation Of Children In The NT
Funder
National Health and Medical Research Council
Funding Amount
$465,859.00
Summary
Almost 1 out of 5 children in remote Aboriginal communities are hospitalised with diarrhoea caused by rotavirus. This study will evaluate the impact of rotavirus vaccination in preventing these hospitalisations. In addition to making sure that vaccination works and that those at highest risk are receiving the benefits, it will assess the indirect impact against other causes of diarrhoea providing, critical information relevant to the vaccine's broader introduction in developing country settings.
Clinical Impact Of Clonal Pseudomonas Aeruginosa In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$547,238.00
Summary
In patients with cystic fibrosis (CF), the normal defence mechanisms are compromised by an inherent genetic fault which results in an extremely sticky and dehydrated mucus. The respiratory system is unable to eradicate microbes (infection) from the lungs of patients with CF which begin to multiply and cause infection and inflammation. Recurring infections are treated with multiple courses of antibiotics and frequent hospitalisation and eventually result in premature death. This study focuses on ....In patients with cystic fibrosis (CF), the normal defence mechanisms are compromised by an inherent genetic fault which results in an extremely sticky and dehydrated mucus. The respiratory system is unable to eradicate microbes (infection) from the lungs of patients with CF which begin to multiply and cause infection and inflammation. Recurring infections are treated with multiple courses of antibiotics and frequent hospitalisation and eventually result in premature death. This study focuses on the major bacterial problem, Pseudomonas aeruginosa. Several studies from Australia and the UK, including our own have shown that about 30% to 45% of patients share the same strain of Pseudomonas aeruginosa within a centre. We know that two dominant strains of Pseudomonas aeruginosa are found in CF centres on the eastern board of Australia. This is unexpected as this bacterium is usually acquired from the environment. The emergence of these clonal strains is causing increasing anxiety in the CF community. This study is designed to provide vitally needed information on the clinical implications of being infected by an clonal strain of Pseudomonas aeruginosa and the risk factors for the acquisition of an clonal strain. This new information will provide a rationale basis for the need for changes to infection control policies (including patient segregation), better outcome predictors for patients infected with clonal strain of Pseudomonas aeruginosa.Read moreRead less
Cluster Randomised Trial Comparing One Versus Two Doses Of Ivermectin For Mass Drug Administration To Control Scabies
Funder
National Health and Medical Research Council
Funding Amount
$540,512.00
Summary
Scabies is a common skin disease in developing countries, in particular in the Pacific region. In the Western Province of Solomon Islands, one in two children suffer from the infestation, and 20% of the population. We know that mass drug administration with two doses of oral ivermectin is effective to reduce the burden of scabies in the community. We now propose a study to determine whether one single dose is as effective. This would have major public health benefits.
Does Mass Drug Administration For Scabies Result In Control Of Serious Bacterial Complications? A Proof Of Concept Towards Global Elimination.
Funder
National Health and Medical Research Council
Funding Amount
$883,760.00
Summary
Scabies is common skin disease in developing countries, in particular in the Pacific region. In Fiji, one in two children suffer from the infestation, which affects over 20% of the population. A recent study conducted in Fiji on 2000 people showed that mass drug administration (MDA) with oral ivermectin is a safe and effective way to reduce the burden of scabies in the community. We will expand the MDA program to 100,000 people, the largest study of MDA ivermectin for scabies ever undertaken.
Anti-sporulation Strategies For Clostridium Difficile Infections
Funder
National Health and Medical Research Council
Funding Amount
$651,559.00
Summary
Hospital-acquired infections with the bacterium Clostridium difficile are a major global public health concern with highly virulent isolates emerging overseas in 2002 and in Australia in 2010. These strains have spread through our hospitals and are also found in the community. This project will increase our understanding of how these strains spread and will provide knowledge that is critical for developing improved strategies for preventing these infections.
Developing a Conceptual Understanding of the Measurement of Length, Area and Volume: Studies of Learning and Teaching. Early numeracy is a priority for the New South Wales Department of Education, which has recently developed a very successful, research-based program for teaching number concepts. The production of a similar program for teaching measurement has been assisted by the recent development of a Framework for Learning Measurement but held back by a lack of research on the validity of t ....Developing a Conceptual Understanding of the Measurement of Length, Area and Volume: Studies of Learning and Teaching. Early numeracy is a priority for the New South Wales Department of Education, which has recently developed a very successful, research-based program for teaching number concepts. The production of a similar program for teaching measurement has been assisted by the recent development of a Framework for Learning Measurement but held back by a lack of research on the validity of that framework. This project will provide the needed research base by studying how students' understanding of measurement concepts develops between Years 1 and 4 and by investigating the effectiveness of teaching based on the Framework. Read moreRead less
Intervention in the Number Learning of Low-Attaining 3rd- and 4th-Graders. In recent years, school systems both in Australia and elsewhere in the world have placed increased emphasis on numeracy. Nevertheless, significant numbers of students finish primary school without successfully learning basic arithmetic. These students have little chance of catching up this learning during the secondary school years and of becoming numerate adults. Australia has pioneered the development of intervention pr ....Intervention in the Number Learning of Low-Attaining 3rd- and 4th-Graders. In recent years, school systems both in Australia and elsewhere in the world have placed increased emphasis on numeracy. Nevertheless, significant numbers of students finish primary school without successfully learning basic arithmetic. These students have little chance of catching up this learning during the secondary school years and of becoming numerate adults. Australia has pioneered the development of intervention programs in the early years of school but there are virtually no established intervention programs in the Years 3-6 range. The project involves the use of innovative methodologies and collaboration with teachers to research and develop successful intervention programs.Read moreRead less
Investigating a classroom simulation designed to support pre-service teacher decision making in planning and implementing literacy teaching. This project investigates teacher mentor and preservice teacher participation in an online simulation of the teaching of literacy in junior primary classrooms. It will investigate how simulation can support preservice teachers to make complex sequences of decisions about the use of language and learning resources, teaching strategies and behaviour managemen ....Investigating a classroom simulation designed to support pre-service teacher decision making in planning and implementing literacy teaching. This project investigates teacher mentor and preservice teacher participation in an online simulation of the teaching of literacy in junior primary classrooms. It will investigate how simulation can support preservice teachers to make complex sequences of decisions about the use of language and learning resources, teaching strategies and behaviour management strategies for a class of virtual students. The simulation will employ embedded cognitive tools to support teacher decision making. Once effective simulation learning of teacher performance is achieved, it will investigate the transfer of these skill to the real classrooms.Read moreRead less
Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge th ....Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge through digital animation and to collaborate with other preservice teachers interstate and internationally. The products and processes of digital animation will help maintain and expand Australia's base as a knowledge economy as well as provide a social benefit of improved science teaching in schools. Read moreRead less
Beyond Bullying in Primary Schools: Explicating Psychosocial Antecedents and Implementing an Effective Intervention to Enhance Pro-Social Behaviour, Well-Being and Academic Engagement. Early intervention to combat bullying in primary schools is vital given the pervasiveness and long-term consequences of bullying for academic failure, mental health costs, and anti-social behaviour. Consistent with National Research Priorities (promoting/maintaining good health & well-being), our research offers i ....Beyond Bullying in Primary Schools: Explicating Psychosocial Antecedents and Implementing an Effective Intervention to Enhance Pro-Social Behaviour, Well-Being and Academic Engagement. Early intervention to combat bullying in primary schools is vital given the pervasiveness and long-term consequences of bullying for academic failure, mental health costs, and anti-social behaviour. Consistent with National Research Priorities (promoting/maintaining good health & well-being), our research offers important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians. Effective intervention and explicating the determinants/consequences of primary school bullying enhances pro-social behaviours, self-concept, mental health, and school engagement of bullies and victims. This fosters safer schools that contribute to individual, local community, and national well-being.Read moreRead less