Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of th ....Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of the establishment of epigenetic state, combined with its heritability during mitosis, provides all the essential components for developmental noise. If our hypothesis proves correct, our work will have a major impact on the understanding of one of the most basic concepts in genetics.Read moreRead less
Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide ....Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.
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Transforming children's mathematical and scientific development: a longitudinal study. An innovative program promoting young children's mathematical and scientific reasoning will be evaluated from grades one to three This study will determine whether an intervention capitalising on children's natural capacity for learning impacts their general cognitive development and problem solving skills at an optimum age.
Global childhoods: Life-worlds and educational success in Australia and Asia. This project aims to investigate how everyday life-worlds of year four students (nine-ten years of age) in Australia, Hong Kong and Singapore shape children’s orientations to educational success. Situated in the global cities of Melbourne, Sydney, Hong Kong and Singapore, the study explores connections between policy contexts, school experiences and everyday activities of children growing up in the Asian Century. Findi ....Global childhoods: Life-worlds and educational success in Australia and Asia. This project aims to investigate how everyday life-worlds of year four students (nine-ten years of age) in Australia, Hong Kong and Singapore shape children’s orientations to educational success. Situated in the global cities of Melbourne, Sydney, Hong Kong and Singapore, the study explores connections between policy contexts, school experiences and everyday activities of children growing up in the Asian Century. Findings will advance knowledge of factors that contribute to children’s understandings of how their experiences in and out of school prepare them for futures in a global world. This will enable policy-makers, educators and parents to provide improved learning opportunities in children’s lives.Read moreRead less
The use of molecular sponges to inhibit small Ribonucleic acid activity in plants. The deletion of gene activity is the most powerful way to understand gene function; however for genes encoding small Ribonucleic acids (RNAs) no current methodology can efficiently achieve this. Here, we aim to develop a gene silencing technology for small RNA encoding genes, which can be utilised to determine their function and used for biotechnological applications.