Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all h ....Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all higher organisms, we expect our community will benefit from the increased knowledge base that will help our researchers adopt new strategies in fighting diseases and improving our agricultural industry.Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
Polymer-functionalised nanotubes: controlled formation by self-assembly. This project will develop new structures of nanotubes by combining peptide sequences and synthetic polymers. These nanostructured materials will form the basis of a wide range of technological applications, such as inorganic nanotubes, ion channels, drug carriers, and more broadly in nanotechnology and nanomedicine.
Manipulative mothers and family feuds: evolution of maternal effects under mother-offspring conflict. Can mothers shape the lives of their offspring and their grand-offspring? Can siblings shape the lives of their brothers and sisters? This project will address how mother and offspring strategies affect current and future generations. This is crucial for understanding how mothers will direct and accelerate evolutionary change in our changing world.
A novel quantitative risk assessment framework for fractured rock slopes. Rock slope instabilities present grave risks to life and to the serviceability of major Australian infrastructure such as mines, roads and railways, and to coastal recreation areas. This project aims at developing tools for the quantitative risk assessment of fractured rock slopes based on rigorous rock mechanics, numerical methods and probabilistic methods.
The research outcomes will improve our understanding of natural ....A novel quantitative risk assessment framework for fractured rock slopes. Rock slope instabilities present grave risks to life and to the serviceability of major Australian infrastructure such as mines, roads and railways, and to coastal recreation areas. This project aims at developing tools for the quantitative risk assessment of fractured rock slopes based on rigorous rock mechanics, numerical methods and probabilistic methods.
The research outcomes will improve our understanding of natural and engineering rock slopes, reduce the uncertainties in the prediction of the safety of infrastructures, and thus minimize the loss and damage. The research outcomes can also be used to maintain workplace safety in mining environments and avoid disruptions to production.
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The impact and cost of short-term health staffing in remote communities. This project aims to examine the impact of the increasing levels of short-term health staffing in remote communities upon service acceptability to patients, workload and attitudes of long-term resident primary health care staff, and the effectiveness and cost of health services. There is a dearth of information about this 'fly in/fly out' (FIFO) workforce in remote communities, which have the worst health outcomes in the co ....The impact and cost of short-term health staffing in remote communities. This project aims to examine the impact of the increasing levels of short-term health staffing in remote communities upon service acceptability to patients, workload and attitudes of long-term resident primary health care staff, and the effectiveness and cost of health services. There is a dearth of information about this 'fly in/fly out' (FIFO) workforce in remote communities, which have the worst health outcomes in the country. The project aims to inform consumers, health practitioners, health service planners and policy-makers about the impact of FIFO, as well as to contribute to the development of strategies designed to stabilise the remote health workforce.Read moreRead less
Staffing practices in Aboriginal primary health care services. This project aims to generate new knowledge about the impact of short-term staffing in remote Aboriginal Community Controlled Health Services on service acceptability to patients, workload and attitudes of long-term staff and the effectiveness and cost of services. The project intends to compare these results to recent findings about the impact of short-term staffing in government-run clinics, in order to quantify and describe the po ....Staffing practices in Aboriginal primary health care services. This project aims to generate new knowledge about the impact of short-term staffing in remote Aboriginal Community Controlled Health Services on service acceptability to patients, workload and attitudes of long-term staff and the effectiveness and cost of services. The project intends to compare these results to recent findings about the impact of short-term staffing in government-run clinics, in order to quantify and describe the potential positive effect of community control. Expected outcomes include rigorous evidence about the 'fly in/fly out' workforce and the impact of community control which can inform new policy that will stabilise the remote health workforce, save money and contribute to 'closing the gap' in health outcomes.Read moreRead less
The use of molecular sponges to inhibit small Ribonucleic acid activity in plants. The deletion of gene activity is the most powerful way to understand gene function; however for genes encoding small Ribonucleic acids (RNAs) no current methodology can efficiently achieve this. Here, we aim to develop a gene silencing technology for small RNA encoding genes, which can be utilised to determine their function and used for biotechnological applications.
The hunt for Ribonucleic Acid riboswitches and genetic sensors of metabolic flux in plants. Ribonucleic Acid (RNA) contains both structural and sequence information that coordinates feedback of metabolic processes in response to environmental change, thereby promoting cellular adaptation and survival. This project will discover ancient RNA modules and structural switches in plants that sense chemical reactions and regulate pathway flux.