Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
Promoting Plant Innovation in Australia: maximising the benefits of intellectual property for Australian agriculture. The development of new plant varieties is crucial to the ongoing competitiveness and sustainability of Australian agriculture. It also has wider social, cultural and economic consequences. Intellectual property laws have the potential to promote and hinder the developments of new plant varieties. In recent years there has been a shift towards the use of patents to protect plant i ....Promoting Plant Innovation in Australia: maximising the benefits of intellectual property for Australian agriculture. The development of new plant varieties is crucial to the ongoing competitiveness and sustainability of Australian agriculture. It also has wider social, cultural and economic consequences. Intellectual property laws have the potential to promote and hinder the developments of new plant varieties. In recent years there has been a shift towards the use of patents to protect plant innovations: a trend which has the potential to transform existing research and development arrangements and industry practices in Australia. By providing policy-makers and stakeholders with recommendations on how to respond to and manage these changes, the project will promote plant breeding in Australia and also enhance the sustainability and competitiveness of Australian agriculture.Read moreRead less
Protection of Botanical Innovation: A legal analysis of the scope and operation of national and international plant breeder's rights. Plants play a crucial role in Australian society: they are a major source of nutrition, shelter, clothing, fuel, medicines and aesthetic pleasure. They also make an important contribution to the Australian economy. The legislative regime established under the 1994 Plant Breeder's Rights Act was designed to promote research, investment and innovation in Australian ....Protection of Botanical Innovation: A legal analysis of the scope and operation of national and international plant breeder's rights. Plants play a crucial role in Australian society: they are a major source of nutrition, shelter, clothing, fuel, medicines and aesthetic pleasure. They also make an important contribution to the Australian economy. The legislative regime established under the 1994 Plant Breeder's Rights Act was designed to promote research, investment and innovation in Australian plant breeding. A lack of familiarity and widespread misunderstanding mean that the system is under-utilised with adverse consequences for plant innovation and Australia's economy. This groundbreaking research will provide a comprehensive analysis of plant breeder's rights in Australia to maximise understanding and awareness amongst key stakeholders.Read moreRead less
Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is a ....Pro-Fluorescent Aryl Nitroxides: New Probes for Polymer Lifetime and Kinetics Research. Internal aryl rings present in novel probes developed for this project impart fluorescence which is efficiently and internally quenched by the presence of a paramagnetic nitroxide group. Scavenging of radicals by the nitroxide however "switches on" the fluorescence and this enables powerful new fluorescence-based detection levels for the technique of nitroxide free radical scavenging. Such sensitivity is applicable to polymerization kinetics studies, as well as providing new means for the determination of materials lifetimes. The development of pro-fluorescent markers as indicators for polymer degradation would be a significant outcome for materials where component failure has a major negative impact.Read moreRead less
Special Research Initiatives - Grant ID: SR0354908
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outco ....The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outcomes and solutions to problems in agriculture, horticulture, forestry and protection of Australia's native flora. Researchers are struggling to create these links, constrained by disciplinary boundaries and geographical isolation. Key industries and researchers already support this proposal.Read moreRead less
Improving Regional Low SES Students' Learning and Wellbeing. This study aims to address the learning and wellbeing needs of over 7000 predominantly low socio-economic status students in regional Australia by researching the conditions that enable refinement and extension of a successful curricular and wellbeing program. The current low educational performance of this student cohort has significant negative effects on individual employment prospects and broader national productivity. Their under- ....Improving Regional Low SES Students' Learning and Wellbeing. This study aims to address the learning and wellbeing needs of over 7000 predominantly low socio-economic status students in regional Australia by researching the conditions that enable refinement and extension of a successful curricular and wellbeing program. The current low educational performance of this student cohort has significant negative effects on individual employment prospects and broader national productivity. Their under-achievement and disengagement from schooling also contribute to many antisocial, harmful short-and long-term outcomes for individuals, with significant health and other costs to the broader community. Outcomes from the project have the potential to improve these current outcomes and to be applicable to similar settings.Read moreRead less
CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule developmen ....CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule development. New knowledge of the plant growth processes through mechanistic analysis of organ induction provides the tools to optimise the legume's productivity, quality, and environment adaptation.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Chemically re-engineering bioactive natural products using fragment based drug design. Current drug and agrichemical discovery technologies are under immense pressure to meet the future pharmaceutical and agriculture demand created by population growth. This project will develop a novel technology concept that re-engineers the chemical features of bioactive natural products optimising medicine and agrichemical discovery.
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less