Detecting, preventing and responding to image-based abuse. This project aims to investigate the efficacy of digital tools and interventions to detect, prevent and respond to image-based abuse (the non-consensual creation or distribution of intimate images). Through a digital ethnography, victim and stakeholder interviews, online surveys, and an AI chatbot, the project expects to generate evidence and theory on both image-based abuse and internet governance. The expected outcomes include: increas ....Detecting, preventing and responding to image-based abuse. This project aims to investigate the efficacy of digital tools and interventions to detect, prevent and respond to image-based abuse (the non-consensual creation or distribution of intimate images). Through a digital ethnography, victim and stakeholder interviews, online surveys, and an AI chatbot, the project expects to generate evidence and theory on both image-based abuse and internet governance. The expected outcomes include: increased understanding of the responsibility of digital platforms and the drivers of image-based abuse; improved platform and service responses; enhanced industry and scholarly collaborations; and harm reduction. Expected benefits include improved laws, polices and practices to tackle image-based abuse.Read moreRead less
Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is ex ....Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is expected to enable a broad array of applications, from agricultural treatments to nasal sprays, by exhibiting responsive behaviour at concentrations much lower than conventional modifiers require. The project will study the responsiveness of the system in single droplet, spray, and coating form as well as an active delivery system.Read moreRead less
Smartdrops - Shaping the future of particle technology. The aim of this project is to develop a particle engineering technology, based on microfluidics, that results in micro-droplets with controlled geometry and morphology. These Smartdrops will be used to target respiratory macrophages for the delivery of inflammatory suppressants, since their dimensions can be controlled to optimise lung deposition and macrophage recognition. The project aims to develop an aerosol inhaler and a series of phys ....Smartdrops - Shaping the future of particle technology. The aim of this project is to develop a particle engineering technology, based on microfluidics, that results in micro-droplets with controlled geometry and morphology. These Smartdrops will be used to target respiratory macrophages for the delivery of inflammatory suppressants, since their dimensions can be controlled to optimise lung deposition and macrophage recognition. The project aims to develop an aerosol inhaler and a series of physico-chemical and in vitro characterisation tools that will be used to study Smartdrop formation, aerosol properties and their interactions with cells. The outcome of this project is intended to be the development of a technology for treating chronic lung inflammation which could also be utilised for a number of other commercial applications.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly ....The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly reduce health risks and costs. They may also be used to enable the development of new inhalation technologies based on electrostatic charge to improve aerosol drug delivery to the lungs of patients with respiratory diseases.Read moreRead less
Production of nano-composite particles for inhalational delivery of combination drugs. The project seeks to create a new particle engineering process for pharmaceuticals. The successful outcome will i) enhance substantially the competitiveness of Australia’s research in functional nanomaterials and advanced biomaterials, and ii) benefit the Australian pharmaceutical industry in developing proprietary pharmaceutical formulations.
Novel nano-composite particles for controlled-release drugs via inhalation. This project will explore a novel nano-medicine technology using nanocrystals in liposomes to design new composite particles to enable optimal release of antibiotics delivered by inhalation. Respiratory infection caused by multidrug-resistant bacteria is a major health problem worldwide. Controlled-release products using liposomes simplify dose regimen and enhance bacterial killing. Currently, aerosolised liposomes are l ....Novel nano-composite particles for controlled-release drugs via inhalation. This project will explore a novel nano-medicine technology using nanocrystals in liposomes to design new composite particles to enable optimal release of antibiotics delivered by inhalation. Respiratory infection caused by multidrug-resistant bacteria is a major health problem worldwide. Controlled-release products using liposomes simplify dose regimen and enhance bacterial killing. Currently, aerosolised liposomes are limited to liquid forms with limited control over release and stability. The project will provide new technology on manufacturing composite powders of antibiotics that may ultimately lead to the development of effective new treatments against drug-resistant bacteria.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100629
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Evolutionary impacts of climate change in Australia’s fossil record. This project aims to identify evolutionary responses to climate change in Australia's fossil record by comparing variation in lizard and frog communities across geological time. Using X-ray techniques on museum specimens, this project will generate a large-scale database for tracking evolutionary shifts in relation to historical climatic events. Expected outcomes include the first anatomical descriptions for many species, filli ....Evolutionary impacts of climate change in Australia’s fossil record. This project aims to identify evolutionary responses to climate change in Australia's fossil record by comparing variation in lizard and frog communities across geological time. Using X-ray techniques on museum specimens, this project will generate a large-scale database for tracking evolutionary shifts in relation to historical climatic events. Expected outcomes include the first anatomical descriptions for many species, filling major gaps in our ability to place fossils in a contemporary framework. This research will demonstrate the value of our national collections for addressing important environmental issues, such as biodiversity, extinction, and future habitat change.Read moreRead less
High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED ....High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED is a challenging, yet ultimately powerful, process with key advantages over current vacuum processing systems, especially with regard to production flexibility, cost and OLED size. The project will provide a functioning technology platform for solution OLED fabrication.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100741
Funder
Australian Research Council
Funding Amount
$372,386.00
Summary
How genomics is shaping healthcare: an ethnographic study. This project aims to generate new understandings of how science and biomedicine are co-producing and shaping healthcare. This will be achieved by combining hospital and laboratory ethnography to examine how genomic data is produced, circulated and applied in clinical settings. The project aims to build a theoretical framework and conceptual understanding of genomic medicine that may be used by practitioners and may inform policy. This pr ....How genomics is shaping healthcare: an ethnographic study. This project aims to generate new understandings of how science and biomedicine are co-producing and shaping healthcare. This will be achieved by combining hospital and laboratory ethnography to examine how genomic data is produced, circulated and applied in clinical settings. The project aims to build a theoretical framework and conceptual understanding of genomic medicine that may be used by practitioners and may inform policy. This project should provide significant benefits such as minimising costs by helping identify and streamline decision-making processes, and by showing how public engagement practices shape patients' and practitioners' approaches to genomics.Read moreRead less