Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for lo ....Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for local lung regions within the body. The image analysis methods developed are intended to enable respiratory researchers to investigate lung function in unprecedented detail, leading to new insights into the workings of this complicated and vital organ. Read moreRead less
Hybrid imaging/modelling: A new paradigm for understanding the lung. Our lungs are essential to sustain our lives, yet the details of lung biomechanics are barely understood because the available tools, imaging, modelling and simulation have significant limitations. Imaging is largely limited to providing structural information; simulation is severely restricted by a lack of validation; and inverse modelling is critically hampered by a lack of spatially resolved inputs. The project’s multidiscip ....Hybrid imaging/modelling: A new paradigm for understanding the lung. Our lungs are essential to sustain our lives, yet the details of lung biomechanics are barely understood because the available tools, imaging, modelling and simulation have significant limitations. Imaging is largely limited to providing structural information; simulation is severely restricted by a lack of validation; and inverse modelling is critically hampered by a lack of spatially resolved inputs. The project’s multidisciplinary team is uniquely positioned to explore these problems through the hybridisation of world-leading functional lung imaging technology with state-of-the-art modelling. This project aims to provide, perhaps for the first time, the capacity to see details with the resolution of imaging, richness of modelling and reliability of the finest measurements.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101133
Funder
Australian Research Council
Funding Amount
$358,551.00
Summary
Linking structure and function: a new approach for understanding the lung. This project aims to develop a powerful analysis tool to measure gas transport and mixing within lungs. This project will study the mechanical workings of the lungs, using an innovative approach for analysis of lung images. The expected outcome of this project is a novel platform for investigation and understanding of lung function. It is anticipated that application of the project outcomes to medical challenges in the lo ....Linking structure and function: a new approach for understanding the lung. This project aims to develop a powerful analysis tool to measure gas transport and mixing within lungs. This project will study the mechanical workings of the lungs, using an innovative approach for analysis of lung images. The expected outcome of this project is a novel platform for investigation and understanding of lung function. It is anticipated that application of the project outcomes to medical challenges in the long-term will lead to improved diagnostics and treatments for lung diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100018
Funder
Australian Research Council
Funding Amount
$362,441.00
Summary
Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution op ....Engineering suspended particle sprays through controlled cavitation. This project aims to use cavitation to engineer particle size in sprays of micronised particles suspended in a propellant, and develop a physical mechanism for this process. Understanding how cavitation affects the size of agglomerates in the liquid phase and droplet size in a spray is critical to developing spray devices that require precise control over the final particle size. This will be achieved through high-resolution optical imaging techniques and synchrotron X-ray diagnostics. This project is expected to provide physical insight with applications for inhaled and topical pharmaceutical sprays, and industry spray drying of food products.Read moreRead less
Advanced adsorbents for gas separations. Efficient purification of natural gas and separation of similarly-sized molecules in gas mixtures is increasingly important in our drive to develop a more sustainable way of living in an energy-constrained world. This project will develop a new class of adsorbents to deliver a level of separation efficiency much higher than that currently in use.
Smart materials from semi-soft particles. This project will combine precision polymer chemistry to material science to develop structured nanoparticles for applications in photonics and shape memory materials.
Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise t ....Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise the design of the access network and the production scheduling in an underground mine in order to maximise value over the life of the operation. The outcome intends to be a new strategic software tools for the sector, underpinning increased efficiency and sustainability of Australian mines as well as international competitiveness.Read moreRead less
Certified evaluation of uncertainty in models of dynamical systems. The purpose of this project is to develop methods which will aid engineers to better analyse the accuracy of models created using experimental data. To support the use of the methods, a toolbox with software implementations will also be developed.
Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisat ....Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisation. To address this, the project plans to develop a 3D moulding process for generating soft materials containing precise channels decorated with defined molecules. Intended outcomes include a fundamental understanding of the 3D moulding process, and new polymers and advanced tools for bioengineers for future applications such as tissue transplants, cell guides for treating spinal cord injuries, soft robotics and microfluidic devices to study cancer metastasis. Read moreRead less
Maximisation of value in underground mine access design. This project represents a major advance in the problem of optimising the mine value associated with the access infrastructure of underground mines and providing powerful planning tools for management. The usefulness to the mining industry of the methods and algorithms the project is pioneering lies in their accuracy, flexibility and generality. Not only can they be used for benchmarking value in the design of specific mines, but they can ....Maximisation of value in underground mine access design. This project represents a major advance in the problem of optimising the mine value associated with the access infrastructure of underground mines and providing powerful planning tools for management. The usefulness to the mining industry of the methods and algorithms the project is pioneering lies in their accuracy, flexibility and generality. Not only can they be used for benchmarking value in the design of specific mines, but they can also determine the profitability or viability of mines under the use of new technologies. This is an important project for ensuring that Australia's mining industry remains efficient and internationally competitive. Given Australia’s economic dependence on mineral resources, it will also benefit the country as a whole.Read moreRead less