Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100025
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
A high-throughput screening and sequencing facility for single cell genomics. Genomics has revolutionised biology, but for most microorganisms this revolution has not arrived because very few can be grown in pure culture. The single cell genomics facility will address this major bottleneck by allowing as little as a single cell in a clinical or environmental setting to be sequenced thereby accelerating new discoveries and outcomes.
eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In ....eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In two parallel model systems we will study corals and reptiles to improve environmental detection while simultaneously obtaining information on their population health. This will foster more efficient conservation of endangered species that are of tremendous importance to our marine and terrestrial ecosystems.Read moreRead less
The molecular evolution of wings in flightless birds. The flightless Australian emu and New Zealand kiwi have small wings, while the extinct moa had none at all. This project will identify the genetic changes that have lead to wing reduction and loss in flightless birds. The results will shed light on the genetic control of forelimb development and how it has evolved.
Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: ....Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: Rhodamnia argentea and Rhodamnia rubescens. By studying the genetic variation in each species, and how this relates to myrtle rust resistance and climate, this project aims to design populations that are genetically diverse, maximally resistant to myrtle rust, and adapted to future climate.Read moreRead less
Expanding and resolving the earliest modern human divergence through DNA. This project aims to expand and resolve the earliest modern human divergence. Although it is clear modern humans emerged from Africa, there is no consensus on the timeline of modern human evolution. Archaeological evidence suggests two contenders: east and southern Africa. Genetic data supports the latter; the team’s own data shows that the southern African KhoeSan click-speaking forager peoples have the oldest extant huma ....Expanding and resolving the earliest modern human divergence through DNA. This project aims to expand and resolve the earliest modern human divergence. Although it is clear modern humans emerged from Africa, there is no consensus on the timeline of modern human evolution. Archaeological evidence suggests two contenders: east and southern Africa. Genetic data supports the latter; the team’s own data shows that the southern African KhoeSan click-speaking forager peoples have the oldest extant human lineages. This project will generate large mitochondrial genome and whole genome sequence data for KhoeSan lineages. This is expected to narrow the time of modern human emergence.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100257
Funder
Australian Research Council
Funding Amount
$446,857.00
Summary
Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and populatio ....Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and population change over time. This information can enable more efficient deployment of biosecurity resources and pave the way for genomics to be used pre-emptively to stop new invasions. This can help make genomics a go-to response to new pest invasions and position Australia at the forefront of genomics-based pest biosecurity.Read moreRead less
Using phylogenomics to record the impacts of climate change, extinction and population fragmentation. This project will use ancient DNA from permafrost-preserved Steppe bison bones and bovid exome capture systems to build a detailed record of the genomic impacts of rapid climate and environmental change at the end of the Pleistocene (30 to 11 kyr). The project will analyse how ancestral genetic diversity is distributed amongst surviving bison populations, and the role of nuclear loci under selec ....Using phylogenomics to record the impacts of climate change, extinction and population fragmentation. This project will use ancient DNA from permafrost-preserved Steppe bison bones and bovid exome capture systems to build a detailed record of the genomic impacts of rapid climate and environmental change at the end of the Pleistocene (30 to 11 kyr). The project will analyse how ancestral genetic diversity is distributed amongst surviving bison populations, and the role of nuclear loci under selection and drift. It will create a novel temporal dataset of genomic adaptation and evolution, and will generate critical data for studies of evolutionary processes such as extinctions, speciation and conservation biology and management.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding o ....Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding of global human genomic variants and provide a range of new targets relevant to medical biology, while significantly improving our knowledge of human genetic history and its consequences in the modern day.Read moreRead less
The genomic landscape of speciation in hominins and other taxa. This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways a ....The genomic landscape of speciation in hominins and other taxa. This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways are central to the speciation process. The framework will be developed using the large genomic datasets available across a range of plant and animal species. Applying the model to a modern human population dataset will elucidate the role introgressed DNA from Denisovan and Neanderthals has played in shaping human evolutionary history and may provide novel insights into the genetic basis of disease.Read moreRead less