Prevention Of Asthma In Young Children Via Immunostimulation
Funder
National Health and Medical Research Council
Funding Amount
$679,683.00
Summary
Persistent asthma is a major problem for Australia yet none of the current therapies do more that control the condition. The long-term solution is to prevent asthma from progressing to the persistent form. The major risk factors are: family history, early allergy and recurrent severe lower respiratory infections (sLRI) in the early life. We will conduct a randomized clinical trial to prevent sLRI using a novel bacterial-derived immunostimulant in infants at high risk of developing asthma.
The prevalence of food allergy (FA) has risen dramatically in the last 20 years. Strong evidence suggests that undetermined lifestyle factors are central to this modern phenomenon. We will develop a CRE in Paediatric FA and Food-related Immune Disorders, providing international leadership in public health initiatives to stem the tide of FA and related disorders. We are uniquely placed to provide evidence-based guidelines that will inform public health policy and clinical care of patients.
What Are The Lifetime Clinical Predictors And Risk Factors For Multiple Phenotypes Of Adult Asthma, COPD And Sleep Disordered Breathing? Following Up The TAHS Cohort From 1st To 6th Decade
Funder
National Health and Medical Research Council
Funding Amount
$1,950,689.00
Summary
Breathing gets impaired and impact on the productivity and quality of life when chronic respiratory diseases rise with ageing. Adult chronic respiratory diseases are major causes of illness and death but there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will provide evidence to guide health policy and clinical management of these diseases. These original findings will be of great importance both nationally and internationally.
Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understand ....Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understanding of OMCG criminal activity across Australia and refined theory development about co-offending in criminal groups. The project will lead to improved policy, legislation and policing practice to prevent OMCG crime and dismantle OMCG criminal networks in more cost-effective ways.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100080
Funder
Australian Research Council
Funding Amount
$405,321.00
Summary
Harnessing the power of ordinary people to prevent cyber abuse. Cyber abuse is a serious social problem that requires an urgent solution. The project aims to improve our understanding of cyber abuse intervention by ordinary citizens by utilising innovative research methods. The project expects to generate new knowledge about the mechanisms of prevention of cyber abuse victimisation and to produce an evidence-based intervention training program. Expected outcomes of this project include a new the ....Harnessing the power of ordinary people to prevent cyber abuse. Cyber abuse is a serious social problem that requires an urgent solution. The project aims to improve our understanding of cyber abuse intervention by ordinary citizens by utilising innovative research methods. The project expects to generate new knowledge about the mechanisms of prevention of cyber abuse victimisation and to produce an evidence-based intervention training program. Expected outcomes of this project include a new theoretical paradigm as well as evidence-based policy recommendations for preventing cyber abuse. These could provide significant benefits, such as reduced physical, psychological and economic costs associated with victimisation and the burden on the police and criminal justice system.Read moreRead less
Viral Infection And TGFbeta Impair Glucocorticoid Activity In Epithelial Cells
Funder
National Health and Medical Research Council
Funding Amount
$617,699.00
Summary
Chronic inflammatory lung diseases like asthma and smokers lung are treated with combinations of anti-inflammatory drugs. Powerful anti-inflammatory types of steroid drugs are used in more severe disease. Even these powerful drugs are sometimes not effective enough. Our work is developing an understanding of how inflammation limits the anti-inflammatory effects of steroids and we are devising ways to overcome this with new drugs. We aim to improve treatment of chronic inflammatory diseases, espe ....Chronic inflammatory lung diseases like asthma and smokers lung are treated with combinations of anti-inflammatory drugs. Powerful anti-inflammatory types of steroid drugs are used in more severe disease. Even these powerful drugs are sometimes not effective enough. Our work is developing an understanding of how inflammation limits the anti-inflammatory effects of steroids and we are devising ways to overcome this with new drugs. We aim to improve treatment of chronic inflammatory diseases, especially those affecting the lung.Read moreRead less
Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence re ....Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence required to inform decisions about the introduction of these schemes, to better understand what victim/survivors want from them, and how such schemes can be effectively operationalised. The findings seek to be relevant to all Australian states and territories as well as international jurisdictions.Read moreRead less
Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a ....Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a more risk-sensitive preventive approach to intimate partner homicides in Australia and overseas, enhancing women’s security and preventing their deaths.Read moreRead less
Understanding the drivers and motivators of extremist violence. Despite intense interest in the issue, our understanding of and ability to respond to extremist violence is limited. This innovative program of research is designed to establish an empirical foundation for understanding and responding to extremist violence in Australia. It aims to examine risk and protective factors for such violence, the needs of those susceptible to committing such acts, and the effectiveness of intervention. Find ....Understanding the drivers and motivators of extremist violence. Despite intense interest in the issue, our understanding of and ability to respond to extremist violence is limited. This innovative program of research is designed to establish an empirical foundation for understanding and responding to extremist violence in Australia. It aims to examine risk and protective factors for such violence, the needs of those susceptible to committing such acts, and the effectiveness of intervention. Findings are expected to inform health, national security, social welfare, and justice agencies in their pursuit to identify those at risk of offending, address their clinical needs and manage the risk of harm they pose to society and to themselves.Read moreRead less
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less