Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychologica ....Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychological burdens to patients' family and community. This project will encourage inter-disciplinary approaches to research and train highly skilled researchers both in neuroscience and nanobiotechnology to advance Australia's industrial competitiveness.Read moreRead less
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Novel Nanostructures of Metal Oxides and Sulfides Intercalated Laponite for Catalytic Applications. The project aims to develop a novel synthesis approach for making nanocomposites of transition metal oxides and sulfides intercalated laponite clay. Such nanomaterials made by integrating template synthesis and intercalation have superior pore and surface properties promising for advanced catalytic applications. The project will provide insights into mechanisms of nanostructure formation and inter ....Novel Nanostructures of Metal Oxides and Sulfides Intercalated Laponite for Catalytic Applications. The project aims to develop a novel synthesis approach for making nanocomposites of transition metal oxides and sulfides intercalated laponite clay. Such nanomaterials made by integrating template synthesis and intercalation have superior pore and surface properties promising for advanced catalytic applications. The project will provide insights into mechanisms of nanostructure formation and interactions of molecular species during synthesis. The best catalysts screened will be tested for two important reactions to establish the relationships between processing parameters, nanostructural properties and catalytic performance. Optimised synthesis parameters for high catalytic performance will be obtained. The project contributes to significant knowledge creation in nanomaterials science and catalysis.Read moreRead less
Single-atom catalysts for electrochemical carbon dioxide conversion. This project aims to develop a new synthetic technique for the fabrication of template-free and metal single-atoms embedded in doped carbon nano tubes. It will generate fundamental knowledge about multiple proton and electron transfer steps in carbon dioxide (CO2RR) using in-situ synchrotron characterisation techniques. Expected outcomes of the research include the development of new single-atom catalysts for production of the ....Single-atom catalysts for electrochemical carbon dioxide conversion. This project aims to develop a new synthetic technique for the fabrication of template-free and metal single-atoms embedded in doped carbon nano tubes. It will generate fundamental knowledge about multiple proton and electron transfer steps in carbon dioxide (CO2RR) using in-situ synchrotron characterisation techniques. Expected outcomes of the research include the development of new single-atom catalysts for production of the key feed-stock of CO for sustainable use in hydrocarbon fuels, providing significant benefits in the reduction of greenhouse emissions.Read moreRead less
Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the re ....Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the realisation of this prospect. This project expects the high performance and technically viable device technologies will enable diamond electronic devices for applications in telecommunications, radars and the next-generation electricity grid.Read moreRead less
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Development of Effective Bentonite Adsorbents for Colour Removal from Wastewater and Process Streams. This project aims to develop cost-effective adsorbents from natural bentonite clay for the removal of colour organics in water and other process streams. A new method for modifying the clays will be developed and investigated systematically. Adsorption of various dyes onto clay-based adsorbents will be examined to obtain a better understanding of the adsorption equilibrium and kinetics. The proj ....Development of Effective Bentonite Adsorbents for Colour Removal from Wastewater and Process Streams. This project aims to develop cost-effective adsorbents from natural bentonite clay for the removal of colour organics in water and other process streams. A new method for modifying the clays will be developed and investigated systematically. Adsorption of various dyes onto clay-based adsorbents will be examined to obtain a better understanding of the adsorption equilibrium and kinetics. The project will study the effects of various parameters to optimise the processing conditions for maximum removal efficiency. The project contributes to the mineral industry in value-adding and will also lead to cost-effective processes for water pollution control.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882357
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering ....A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering/purifying water and gases. The dedicated computing facility will enable a fast interactive cycle between simulation and experiment in these areas, accelerating the pace of research and applications.Read moreRead less
Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organism ....Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organisms’ responses to nanoparticles at the cellular, enzymatic and gene expression levels. The findings are expected to help assess the immediate and long-term effect of nanoparticles on ecosystem health, for improved environmental management.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less