Multicentre Trial Of Calcium Channel Blocker Versus Calcium Channel Blocker Plus Cox2 Inhibitor In Preterm Labour
Funder
National Health and Medical Research Council
Funding Amount
$644,130.00
Summary
Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throug ....Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throughout Australia, along with overseas centres. It will test a new combination of drugs for their ability to postpone delivery in women presenting with preterm labour. It is postulated that the combination of drugs will be more effective than existing therapies. The drugs used in the trial are Nifedipine and Rofecoxib. Complications of prematurity include neonatal death, cerebral palsy, visual and hearing impairment, and chronic lung disease. These complications are most significant in extremely premature infants - in particular, those under 28 weeks gestation at the time of their delivery. For this reason, the study will focus only on women presenting in labour below 28 weeks. The ability to stop labour is important, but the main aim of any treatment for preterm labour is to reduce the rates of neonatal death and handicap. Babies born to women enrolled in this study will be followed for a period of one year after birth to assess their outcomes. It is our hypothesis that the combination of Rofecoxib and Nifedipine will result in lower rates of death and handicap in babies than Nifedipine alone. In addition, we will examine the rates of side effects in women receiving therapy. Currently used therapies, including intravenous ventolin, have high rates of maternal side effects. Nifedipine and Rofecoxib have both been shown to have low rates of maternal side effects.Read moreRead less
Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Understanding The Myometrial Transition At Term And Preterm Labour To Guide Tocolysis
Funder
National Health and Medical Research Council
Funding Amount
$808,447.00
Summary
This grant seeks to understand how the muscle cells of the uterus transform at the time of labour. We propose that this transformation is organised by enzymes that modify the histones around key genes. We will test if a similar pathway operates in cases of preterm labour. The results will guide the development of new ways of treating premature labour that will use targeted nanoparticles to deliver siRNA directly to the muscle cells of the uterus.
Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement i ....Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement income and public pension receipt. The project will develop a new tax records-based dataset to facilitate future research on tax and welfare systems.Read moreRead less
Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the firs ....Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the first time provide critical empirical evidence on the possible need to separate policy measures aimed at rural vs. urban employers. The outcomes will contribute to reducing the problem of critical skill shortages and wastage at once and do so with an eye to the needs to rural Australia – a key driver of the country’s exports. Read moreRead less
Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor men ....Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor mental health influences the types of jobs that people enter into. This should provide significant benefits, including evidence needed to improve existing workplace and employment programs, and evidence ensuring that assistance is efficiently targeted to those workers and industries with the greatest need.Read moreRead less
Impact Of Extreme Prematurity Or Extreme Low Birthweight On Young Adult Health And Well-Being: The Victorian Infant Collaborative Study (VICS) 1991-92 Longitudinal Cohort
Funder
National Health and Medical Research Council
Funding Amount
$725,496.00
Summary
Significant advances in medical care have increased survival of the tiniest and most premature babies. Those who have benefited from modern medicine are now in their mid-20s. We know they have more problems in childhood and adolescence compared with those born full term. However, we know little about their health problems in adulthood. This study will inform us of adult health problems in this vulnerable group and provide vital information about the best care for this increasing group of adults.
Living on the Margin: The Relationship between Mental Health and Work in Australia. This project will assess the relationship between Australians' mental health and their work, for example, employment status, work conditions and hours. The study is the first to exploit the detailed timing of mental health and employment transitions to identify whether poor labour market outcomes lead to poor mental health or whether the reverse is true. New Australian data will be used to understand whether the ....Living on the Margin: The Relationship between Mental Health and Work in Australia. This project will assess the relationship between Australians' mental health and their work, for example, employment status, work conditions and hours. The study is the first to exploit the detailed timing of mental health and employment transitions to identify whether poor labour market outcomes lead to poor mental health or whether the reverse is true. New Australian data will be used to understand whether the link between mental health and work adds to the economic vulnerability of families and those at risk of homelessness. The results will advance our understanding of the way that mental health affects overall economic well-being and will inform current policy initiatives to promote economic participation and good mental health.Read moreRead less
Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to he ....Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to help shape policy recommendations on the funding of tertiary education in a changing economic climate. This should provide significant benefits to Australians, as policies shaping the tertiary education system affect individual income and the aggregate economy by determining labour supply and taxpayers' financial burden.Read moreRead less
Human Capital, Cognitive Skills and Labour Market Outcomes. As Australia competes in the ‘educational race,’ this project will generate new knowledge on the relationship between education, skill attainment and economic outcomes in Australia. The research will provide new empirical evidence on cognitive and non-cognitive skills formation over the life-cycle, and the relationship between these skills and labour market outcomes in Australia within the broader international context. The research wil ....Human Capital, Cognitive Skills and Labour Market Outcomes. As Australia competes in the ‘educational race,’ this project will generate new knowledge on the relationship between education, skill attainment and economic outcomes in Australia. The research will provide new empirical evidence on cognitive and non-cognitive skills formation over the life-cycle, and the relationship between these skills and labour market outcomes in Australia within the broader international context. The research will advance methodological techniques for the economic analysis of cognitive skills and their economic impacts. The research will inform public policy formulation relating to educational attainment, skill development, and strategies to encourage longer workforce engagement over the life-cycle.Read moreRead less