The Role Of Non-classical MHC Class I Molecules In Adaptive Immunity
Funder
National Health and Medical Research Council
Funding Amount
$443,834.00
Summary
Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.
Functional Suicide Of Selected Dendritic Cells By Cytochrome C: An In Vivo Model Lacking Cross-presentation
Funder
National Health and Medical Research Council
Funding Amount
$597,476.00
Summary
Certain white blood cells (dendritic cells) activate the immune system, especially its T cells. Infection of such cells elicits killer T cell responses. However not all infections infect dendritic cells. In such cases, the infectious material is eaten by dendritic cells and moved to certain areas within the cell. This process is called cross-presentation and how important it is during various diseases remains moot. We now have a model of testing this by eliminating these cross-presenting cells.
Supporting adaptive diagrammatic communication. The computing environment of the near future will allow users to access and
interact with digital information using an incredible variety of devices.
Regardless of these changes, humans will still be communicating using
diagrams and sketches. But unlike today where diagrams are static,
lifeless objects reflecting their origin in print media, the computer of
the near future will provide more flexible visual computer interfaces which
support ....Supporting adaptive diagrammatic communication. The computing environment of the near future will allow users to access and
interact with digital information using an incredible variety of devices.
Regardless of these changes, humans will still be communicating using
diagrams and sketches. But unlike today where diagrams are static,
lifeless objects reflecting their origin in print media, the computer of
the near future will provide more flexible visual computer interfaces which
support adaptive layout, user interaction and semantics based retrieval.
Based on geometric constraint solving, this project will provide a
generic computational basis for this radically new view of diagrams.
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Minimising the inappropriate and unnecessary hospital admissions of frail older people. The health system will continue to experience massive pressures in both fiscal and human resource terms. Older patients present with multiple, complex conditions and tend to be admitted because clinicians often do not have the time to explore other options. This project will develop and evaluate a unique and robust model for minimising inappropriate hospital admissions through rapid assessment of suitability ....Minimising the inappropriate and unnecessary hospital admissions of frail older people. The health system will continue to experience massive pressures in both fiscal and human resource terms. Older patients present with multiple, complex conditions and tend to be admitted because clinicians often do not have the time to explore other options. This project will develop and evaluate a unique and robust model for minimising inappropriate hospital admissions through rapid assessment of suitability for home care and complete referral information for safety and quality. Read moreRead less
Protecting Web Services from Distributed Denial of Service Attacks. Distributed denial-of-service (DDoS) attacks bring a tremendous threat to web services on the Internet. Large amount of web services were pulled down worldwide by the DDoS attacks, with huge losses in business. Effective approaches to defeat DDoS attacks are desperately demanded. Most existing DDoS defense systems aim to only protect the victim network and are not fully integrated. In this project we propose a novel defense syst ....Protecting Web Services from Distributed Denial of Service Attacks. Distributed denial-of-service (DDoS) attacks bring a tremendous threat to web services on the Internet. Large amount of web services were pulled down worldwide by the DDoS attacks, with huge losses in business. Effective approaches to defeat DDoS attacks are desperately demanded. Most existing DDoS defense systems aim to only protect the victim network and are not fully integrated. In this project we propose a novel defense system to protect web services from DDoS attacks. Our system is one of the first systems that have a mixture deployment in both victim end and attack source end, and integrated capabilities of intrusion surveillance, traffic control, and traceback, thus achieve better control results over other mechanisms.Read moreRead less
The School: Designing a dynamic venue for the new knowledge environment. This project addresses a problem of real concern in relation to national and state government policies for promoting an innovation culture and economy. This project does this at the base level of schools by creating effective education learning environments that will encourage creative and innovative citizens of the future. This detailed examination of the collaborative design process and the day to day functioning of the p ....The School: Designing a dynamic venue for the new knowledge environment. This project addresses a problem of real concern in relation to national and state government policies for promoting an innovation culture and economy. This project does this at the base level of schools by creating effective education learning environments that will encourage creative and innovative citizens of the future. This detailed examination of the collaborative design process and the day to day functioning of the physical setting, including the use of smart technologies, focusing on stakeholder needs for 21st Century success, will assist in identifying the role of intelligent design in assisting a schools to deliver education for innovation.Read moreRead less
Interest-based negotiation: theory and practice. The results of the project will provide theoretically sound technologies that can better support distributed resource and task allocation in complex problem solving settings. The combination of theoretical and practical outcomes from the research will enable these technologies to be applied in decision-making settings beyond those studied directly in the project. The project contributes to Australia's ability to compete in the emerging internation ....Interest-based negotiation: theory and practice. The results of the project will provide theoretically sound technologies that can better support distributed resource and task allocation in complex problem solving settings. The combination of theoretical and practical outcomes from the research will enable these technologies to be applied in decision-making settings beyond those studied directly in the project. The project contributes to Australia's ability to compete in the emerging international market for knowledge-based software applications. The project's key connections and integration with European research will also strengthen research collaboration and training opportunities for Australian based students. Read moreRead less