Developing A Screening Test To Identify Women At Risk Of Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$1,119,284.00
Summary
Preeclampsia is a serious complication of pregnancy for which there is currently no cure and no way to accurately predict women at risk. Using large collections of human blood samples, we will screen for novel proteins within pregnant women's blood. We will then use artificial intelligence to select the best biomarkers and combine them with clinical information to develop a multi-marker blood test to predict women at risk.
Personalised Nutrition To Revolutionise Gestational Diabetes Prevention
Funder
National Health and Medical Research Council
Funding Amount
$854,008.00
Summary
Gestational diabetes (GDM) affects 1 in 7 pregnant women, significantly increasing future risk for cardiovascular diseases in women and offspring. Clinical management of GDM is a healthy diet; but this one-size fits all approach is ineffective. We need to prevent GDM. We will use dietary modelling to inform culturally acceptable, personalised nutrition plans that will reverse metabolic risk factors to prevent GDM. Personalised nutrition represents a paradigm shift for current clinical care.
A Novel Interaction Between The Immune And Vascular Systems In Early-onset Preeclampsia; An Opportunity For New Treatments?
Funder
National Health and Medical Research Council
Funding Amount
$921,623.00
Summary
Preeclampsia is a pregnancy complication that leads to poor birth outcomes and elevated lifelong cardiovascular disease risk in 4 million women each year. It has no cure and treatments are limited because the causal mechanisms are not understood. We have identified a specialised immune cell in the mother's blood that assists blood vessels to function properly in pregnancy. We will assess whether interventions to enhance these cells can improve poor blood vessel function and pregnancy outcomes.