Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The m ....Identification of novel biomarkers in tears for prostate cancer diagnosis and prognosis. The purpose of this study is to identify novel biomarkers in the tears of patients with CaP. The use of the several techniques will increase the chance of success and enable us to find more diagnostic markers. If successful, the identified proteins may be used to diagnose and determine the stage of cancer. This will help guide clinicians in choosing the best treatment methods for an individual patient. The markers may also be used to monitor the disease progress and the effects of treatment. The results from this study may improve the prognosis of CaP patients.Read moreRead less
Identification of novel biomarkers for diabetic retinopathy in tears. There are around 134,000 people with diabetic retinopathy in Australia. The disease affects patients' physical and mental state and economical and social cost is enormous. This research aims to find new biomarkers for the disease which may lead to better treatment and management. Patient's quality of life may be significantly improved by early diagnosis and treatment and the burden to the community reduced. This project also g ....Identification of novel biomarkers for diabetic retinopathy in tears. There are around 134,000 people with diabetic retinopathy in Australia. The disease affects patients' physical and mental state and economical and social cost is enormous. This research aims to find new biomarkers for the disease which may lead to better treatment and management. Patient's quality of life may be significantly improved by early diagnosis and treatment and the burden to the community reduced. This project also gives industrial partners the opportunity to develop new products to diagnose and monitor the disease.Read moreRead less
Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity ....Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity for the development of mass spectrometry based technologies for the early clinical diagnosis of metabolic disorders plus provides a template of information for our Linkage partner (AstraZeneca) to develop pharmaceutical therapies targeting key molecular lipid species identified as critical to particular membrane functions.Read moreRead less
Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing ....Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing to their design simplicity and low cost of components, the devices developed in this program will lend themselves well to the development of new commercial technologies for Australia.Read moreRead less
Development of novel fluorescent proteins from marine organisms for in vivo fluorescence imaging technologies and cancer research. The Australian Great Barrier Reef (GBR) is a national treasure and the development of fluorescent proteins (FPs) from reef organisms for in vivo imaging and biotechnology will enhance the appreciation of this resource. Nowadays, imaging of biochemical processes in living cells is essential for knowing the roles of various genes and proteins in health and diseases. Th ....Development of novel fluorescent proteins from marine organisms for in vivo fluorescence imaging technologies and cancer research. The Australian Great Barrier Reef (GBR) is a national treasure and the development of fluorescent proteins (FPs) from reef organisms for in vivo imaging and biotechnology will enhance the appreciation of this resource. Nowadays, imaging of biochemical processes in living cells is essential for knowing the roles of various genes and proteins in health and diseases. The global market for fluorescence-based products is estimated in billions of dollars p.a. The discovery of natural FPs from GBR with superior molecular, biophysical and optical characteristics to those of commercially available FPs offers a unique opportunity to develop advanced tools to study cellular processes and develop diagnostic assays for diseases such as cancer.Read moreRead less