Markers Of Androgen Action, Genetic Variation And Prostate Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$798,907.00
Summary
This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic va ....This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic variants in 4 candidate genes in the hormonal pathway. The established risk factors for prostate cancer are only age, race and family history. We anticipate that this project will cast light on the role of hormones in prostate cancer and that we will identify new markers of risk of prostate cancer and markers of disease aggressiveness. These outcomes will help us identifying men who are at risk for prostate cancer to target screening and surveillance, and plan prevention strategies. Furthermore, they will also form the basis for research on treatment targets.Read moreRead less
Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised count ....Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised countries).Read moreRead less
Developing a disability policy model to target the prevention or reduction of limitations on functioning and wellbeing. With the ageing of Australian society the challenge for public health is shifting from preventing death and disease onset to supporting healthy and productive ageing. The disability policy model will allow cost-effective targeting of interventions to reduce or prevent onset of disability or reduce its severity particularly among older Australians.
Understanding personal, social and environmental influences on nutrition and physical activity among older adults living in urban and rural areas. There are negative impacts of obesity, poor diet and physical inactivity on physical, psychological and social wellbeing and national economic costs associated with these burdens are substantial. Obesity and its associated illnesses are estimated to cost Australian health services $1.2 billion a year. An understanding of the modifiable determinants of ....Understanding personal, social and environmental influences on nutrition and physical activity among older adults living in urban and rural areas. There are negative impacts of obesity, poor diet and physical inactivity on physical, psychological and social wellbeing and national economic costs associated with these burdens are substantial. Obesity and its associated illnesses are estimated to cost Australian health services $1.2 billion a year. An understanding of the modifiable determinants of nutrition and physical activity behaviours is required in order to develop effective interventions to promote health and well-being. Promoting physical activity and a healthy diet thus has the potential to substantially reduce the burden of disease in Australia and improve quality of life.Read moreRead less
Understanding individual, workplace and system level influences on return to work in a changing Australian labour market. This project will identify where challenges arise in return to work after a work-related injury or illness for older workers and people with mental stress claims. The results of this project will help form the basis of policy and program changes to address these issues and enable these groups of workers to have better health and economic outcomes.
Discovery Early Career Researcher Award - Grant ID: DE120101580
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The impact of the ageing workforce on work injury and compensation systems in Australia. This project seeks to better understand important questions related to work injury and its consequences within the context of the ageing Australian labour market. These include understanding how occupational and age-related factors impact on the risk of work injury and if the relationship between age and recovery and safe return to work after injury.
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Improving methods of grading, transferring and facilitating translation of knowledge in population health. This project will develop methods by which research in population health can be better used by policy makers. It will develop a grading system to assist research consumers to work out the best evidence. Interviews and surveys of policy makers will be conducted to work out how to optimise the way the best evidence can be used in practice.