Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' d ....Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' depends on an informed understanding of previous and current expectations about and attitudes to ageing in Australia. The history of old age is a complex rather than simple story, and successful policy development will require a solid historical foundation.Read moreRead less
Does climatic thermal variability matter? This project aims to research how annual and daily variability in temperature effects the distribution of species, their tolerance to temperature, their dispersal ability and genetic structuring. Expected outcomes include more accurate assessment of the ecological risk of climate change, which is expected to result in altered average temperatures and temperature variability. Such assessments will result in better management of species and ecosystems faci ....Does climatic thermal variability matter? This project aims to research how annual and daily variability in temperature effects the distribution of species, their tolerance to temperature, their dispersal ability and genetic structuring. Expected outcomes include more accurate assessment of the ecological risk of climate change, which is expected to result in altered average temperatures and temperature variability. Such assessments will result in better management of species and ecosystems facing threats from climate change.Read moreRead less
Understanding the mechanisms of thermal acclimation in the symbiotic algae (Symbiodinium) within cnidarian corals. Global warming is a major threat to coral reefs, contributing to devastating coral bleaching. This project will provide new insight into how coral reefs can respond to rising global temperature through clarifying the thermal acclimation mechanisms in corals using molecular techniques.
Involvement of cell coupling in vascular function: Development of a computational model. Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable ....Involvement of cell coupling in vascular function: Development of a computational model. Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable us to develop a computational model of the vascular wall and so predict how changes in electrical properties, as occur during pressure changes, can influence blood flow. Since ageing is accompanied by an increase in blood pressure, our results will contribute to a better understanding of blood flow regulation in our ageing population.Read moreRead less
Oil Palm and Agrarian Transition on the Indonesian and Malaysian Frontiers. Challenges to peace and security in Southeast Asia emerge from uneven economic development and agricultural and environmental changes that marginalize vulnerable communities, exacerbate tensions and lead to endemic local level conflicts. This project will explore the linkages between agrarian and environmental change, governance systems and conflict by studying how policy and economic developments are affecting rural co ....Oil Palm and Agrarian Transition on the Indonesian and Malaysian Frontiers. Challenges to peace and security in Southeast Asia emerge from uneven economic development and agricultural and environmental changes that marginalize vulnerable communities, exacerbate tensions and lead to endemic local level conflicts. This project will explore the linkages between agrarian and environmental change, governance systems and conflict by studying how policy and economic developments are affecting rural communities. It will produce a comparative study that will be relevant to policy discussions and scholarship and of interest to donor agencies and practitioners as well as educational institutions and the wider international research community.Read moreRead less
Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and pro ....Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and provide more informed advice to the public on the necessity of avoiding exposure to air pollutants. These two outcomes are particularly important given Australia's ageing population and the fact that the elderly are among those most susceptible to harm from air pollution exposure.Read moreRead less
Coping with temperature extremes: morphological constraints on leaf function in a warmer, drier climate. This project will determine how hydraulic properties of temperate, evergreen leaves affect their capacity to cope with seasonal variation in temperature extremes. The results will enhance mechanistic understanding of temperature tolerance, and inform prediction of vegetation change in response to climate warming and increasing CO2 concentrations.
Fiddling while home burns: climate change and fiddler crabs. Climate change is already affecting many Australian animals, including fiddler crabs. This project will use extensive knowledge of fiddler crab biology to determine whether they can behaviourally compensate for the rapid changes that are occurring by using experiments and observations conducted under natural conditions in the mangroves of Darwin harbour.
THE SOCIAL AND CULTURAL HISTORY OF DEATH AND BEREAVEMENT IN AUSTRALIA AND ENGLAND, 1914-1980. Death, bereavement and old age come to us all, but their history has been neglected for twentieth century Australia and England. I aim to write two substantial books and several articles on this vitally important subject, explaining how and why emotional and expressive death practices and attitudes were often transformed after 1918 into a silence about death, with minimal ritual and privatised grief. Th ....THE SOCIAL AND CULTURAL HISTORY OF DEATH AND BEREAVEMENT IN AUSTRALIA AND ENGLAND, 1914-1980. Death, bereavement and old age come to us all, but their history has been neglected for twentieth century Australia and England. I aim to write two substantial books and several articles on this vitally important subject, explaining how and why emotional and expressive death practices and attitudes were often transformed after 1918 into a silence about death, with minimal ritual and privatised grief. This comparative project has crucial outcomes for our understanding of the histories of medicine, war, religion and the family, as well as policy implications for current issues such as euthanasia, suicide, aged care, cancer and palliative care.Read moreRead less