Optimizing Outpatient Parenteral Antibiotic Therapy To Support Hospital-in-the-home Program Across The Unique Environmental Conditions Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to solve problems associated with stability and dosing of antibiotic infusions given to patients in their homes, to support decision making by doctors and regulators. Currently, there is a lack of adequate data that complies with contemporary requirements. We will study infusion preparation both in laboratory settings and in ‘real-life’ conditions while being used by patients. We will enhance the stability of antibiotic preparations and optimize doses for effective treatment.
A Worm-free World: Defeating Parasitic Helminths Via Global Integrated Control
Funder
National Health and Medical Research Council
Funding Amount
$2,714,215.00
Summary
My research goal is to conquer parasitic worm infestations globally. These parasites cause substantial illness and affect the poorest people. Programs that drug-treat infected individuals are neither effective nor sustainable. My research has shown additional strategies, such as vaccination and health education, are needed. My goal is to develop and field test a combination of interventions in different settings leading to long-term control and elimination of these ancient human scourges.
Towards Evidence-based Use Of IVF Add-ons In Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
A large number of extra ‘add-on’ treatments are available which claim to increase the chance of success of IVF. However, there is no evidence that these add-ons are safe or effective, and they can cost patients up to $2000. I will undertake research to measure use of add-ons in Australia and the factors that drive supply and demand. I will use this information to develop resources based on robust evidence which will help guide patients and clinicians in making decisions about using IVF add-ons.
Better Evidence More Rapidly Implemented To Optimise Health For People With Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$2,914,215.00
Summary
Musculoskeletal conditions place a huge burden on the world’s population. There remain large gaps in the evidence, large delays in getting evidence into practice and policy, and large societal and clinician misconceptions about best care for these conditions. My focus for the next five years will be to improve outcomes for people with musculoskeletal conditions through better evidence, more rapid uptake of evidence into practice, and better strategies to reduce low-value care.
Improving The Neurological And Mental Health Of Vulnerable Children: Through Implementation And Health Services Research To Close Treatment Gaps
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
This Emerging Leader fellowship will support research to improve child neurodevelopmental and mental health. The program of research will answer several of the crucial research questions expressed in the Oct 2019 Productivity Commission Mental Health Report, the 2018 National FASD Strategy, the 2018 Senate Mental Health Inquiry Report, the 2018 Lancet Commission for Mental Health, the 2018 MRFF Strategic Priorities, and 2018 WHO National Strategy for Australian Telehealth Discussion paper.
Improving The Synthesis Of Medical Research: The Evidence Synthesis Taxonomy Initiative
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
People who make decisions regarding the health of individuals or a society need trustworthy information to support these decisions, whether they be about the effectiveness of a strategy, the burden of a disease, the accuracy of a medical investigation or the preferences and values of a population. To produce trustworthy evidence, we need to collate and synthesise all of the information available. This work will improve the science behind evidence synthesis and the quality of evidence synthesis.
A Risk Stratification Tool For The Prevention Of Avoidable Perinatal Mortality And Morbidity
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidi ....Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidity.Read moreRead less
Healthy Lungs For Life: A Life Course Approach To Reduce COPD
Funder
National Health and Medical Research Council
Funding Amount
$2,491,398.00
Summary
Chronic Obstructive Lung Disease (COPD) causes breathing distress, disability and premature death. I have shown that COPD mostly has its origins in childhood. This means we can now identify early life risk factors to prevent COPD or help us catch it early, to improve health. My 5-year vision is to reduce the dire burden of COPD by creating evidence to change guidelines and policy and facilitating the transfer of that knowledge to practice.
Genomics For Combating Antimicrobial Resistant Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$2,027,364.00
Summary
Applying genomics to bacterial pathogens is revolutionising the way we understand infectious diseases and antimicrobial resistance (AMR). There is a major opportunity to now bring the technology into routine clinical and public health practice. This research program will investigate and deliver the technology of pathogen genomics directly into public health disease surveillance, outbreak detection and the diagnosis and response to infectious diseases and AMR in hospitalised patients.
Advancing The Radical Cure Of Plasmodium Vivax Malaria Through Optimal Antimalarial Regimens
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
Forty percent of the global population are at risk of vivax malaria and its associated morbidity. Complete cure of vivax malaria can result in severe anaemia caused by adverse effects of primaquine in vulnerable individuals. My research will provide important evidence for national malaria programs and clinicians, identifying the optimal dosing regimen across different ages and locations, that balances the risks and benefits of primaquine treatment.