Pharmacogenetics Of Methadone Maintenance Treatment
Funder
National Health and Medical Research Council
Funding Amount
$355,564.00
Summary
There is large amount of inter-individual variability in response to methadone use in dependence programmes. Many factors are involved including age, disease and the use of other drugs. Until recently a person's genetic makeup was not amongst these factors. Our study will show how genetic variability that alters the transport or the drug target in the body impacts on a person's drug response and side effects to methadone used to treat opioid dependence.
The Effect Of Iron Supplementation In Pregnancy On Child Cognitive Development
Funder
National Health and Medical Research Council
Funding Amount
$91,562.00
Summary
During fetal life the brain grows very rapidly and animal studies have shown that inadequate iron nutrition of mothers during pregnancy can result in permanent structural and developmental problems in the offspring. Although this has not been examined in human infants, new studies suggest that the iron stores of the mother in pregnancy are an important determinant of the baby's iron stores during the first year of life. It may be that the critical period where iron nutrition influences later dev ....During fetal life the brain grows very rapidly and animal studies have shown that inadequate iron nutrition of mothers during pregnancy can result in permanent structural and developmental problems in the offspring. Although this has not been examined in human infants, new studies suggest that the iron stores of the mother in pregnancy are an important determinant of the baby's iron stores during the first year of life. It may be that the critical period where iron nutrition influences later development is in fetal life (during pregnancy). We have the opportunity to test whether iron nutrition in fetal life influences childhood development by assessing the cognitive abilities of children who were in our earlier study of iron supplementation in pregnancy. Our aim is to assess the children at 4 years to determine if iron nutrition in pregnancy predicts development. This may change the dietary advice we give pregnant women to ensure they give their babies the best start in life.Read moreRead less
A Case-control Study Of Rotavirus Vaccine Effectiveness Against Gastroenteritis Hospitalisation Of Children In The NT
Funder
National Health and Medical Research Council
Funding Amount
$465,859.00
Summary
Almost 1 out of 5 children in remote Aboriginal communities are hospitalised with diarrhoea caused by rotavirus. This study will evaluate the impact of rotavirus vaccination in preventing these hospitalisations. In addition to making sure that vaccination works and that those at highest risk are receiving the benefits, it will assess the indirect impact against other causes of diarrhoea providing, critical information relevant to the vaccine's broader introduction in developing country settings.
Predictive Models And Interventions For Coronary Heart Disease In Aboriginal And Torres Strait Islander People
Funder
National Health and Medical Research Council
Funding Amount
$203,125.00
Summary
The main causes of heart disease in western countries are smoking, high blood pressure and high cholesterol. However, in indigenous populations, other factors may be more important. We propose to look at these conventional risk factors and others like diabetes, blood clotting disorders and inflammation to see which are best for predicting heart attack in Aboriginal and Torres Strait Islander people . We will also examine the effect of heart disease prevention programs run by communities, to see ....The main causes of heart disease in western countries are smoking, high blood pressure and high cholesterol. However, in indigenous populations, other factors may be more important. We propose to look at these conventional risk factors and others like diabetes, blood clotting disorders and inflammation to see which are best for predicting heart attack in Aboriginal and Torres Strait Islander people . We will also examine the effect of heart disease prevention programs run by communities, to see if they can improve these risk factors. Finally, we will use this information to produce educational materials and clinical tools for health services.Read moreRead less
Adolescent Alcohol And Tobacco Use/abuse: The Efficacy Of A Brief Motivational Interviewing And Skills Training Program
Funder
National Health and Medical Research Council
Funding Amount
$153,610.00
Summary
Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health conse ....Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health consequences of heavy drinking and smoking are now well documented. There are many studies exploring the effectiveness of universal prevention programs designed to reduce the chance of alcohol and tobacco problems in high school students. These are associated with short term reductions in the chance of smoking and heavy drinking, however it is unclear whether these programs work for adolescents who are at high risk of alcohol problems and sustained smoking. We know a lot about the sorts of risk factors associated with these problems. They include early onset of use, parental involvement and use, particular personality traits, poor marks, peer use, and poor social skills. There is no research that clearly evaluates prevention programs for adolescents who show these risk factors. In this research, a program tailored for high-risk adolescents will be compared to an educational program similar to what is often received in Australian high schools. It is expected that high-risk students will not show changes in the educational program, but will show long-term improvements after completing the enhanced program. If these results hold, the research will have very important implications for detecting high-risk students and modifying the ways in which these adolescents are treated so that we minimise the chance of further development of alcohol and tobacco problems. This could result in large health cost savings in the future.Read moreRead less
Glucose, Glucose Transporters And Blastocyst Formation In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$281,650.00
Summary
Embryo-based biotechnologies have the potential to improve human reproductive health, notably in treating infertility by In vitro fertilisation (IVF). They are also central to the future use of embryonic stem cells for human tissue replacement. This project investigates the molecular mechanisms controlling one of the earliest differentiations in the growth of the embryo. Using the mouse as an experimental model it will investigate the importance of several factors in the changes which set up the ....Embryo-based biotechnologies have the potential to improve human reproductive health, notably in treating infertility by In vitro fertilisation (IVF). They are also central to the future use of embryonic stem cells for human tissue replacement. This project investigates the molecular mechanisms controlling one of the earliest differentiations in the growth of the embryo. Using the mouse as an experimental model it will investigate the importance of several factors in the changes which set up the placenta and fetus as seperate tissues in the very early embryo. A key focus is the supply of glucose to the newly fertilised embryo and how important this glucose supply is for the survival of the embryo. Moreover there is great interest in the possibility that metabolic events in utero can contribute to the development of diseases in later life, notably, coronary heart diease, stroke, high blood pressure and non-insulin dependent diabetes. The results from these studies will contribute to our understanding of why some couples are infertile, lead to improved management of infertility by diet and invitro fertilisation procedures. It will also be of benefit in dietary advice to women with diabetes mellitus, seeking to have children. The adenoviral strategy for gene delivery into early mouse embryos may in the long term also find wide clinical application in the treatment of genetic defects at the very earliest stages in development and as such is of enormous potential benefit in the management of both animal and human reproduction.Read moreRead less
Prevention Of Anxiety And Depression In Children - Development And Evaluation Of A Universal Lifeskills Program
Funder
National Health and Medical Research Council
Funding Amount
$274,094.00
Summary
The purpose of this study is to develop and evaluate a universal school-based mental health promotion program aimed at preventing anxiety and depression in upper primary school students. The program will build on validated methods of increasing resilience and optimism in young people (Jaycox et al., 1994; Clarke et al., 1995; Dadds et al., 1997; Roberts et al., 1998, Shochet et al., 1998). No other prevention programs have addressed both anxiety and depression, nor have they integrated their pro ....The purpose of this study is to develop and evaluate a universal school-based mental health promotion program aimed at preventing anxiety and depression in upper primary school students. The program will build on validated methods of increasing resilience and optimism in young people (Jaycox et al., 1994; Clarke et al., 1995; Dadds et al., 1997; Roberts et al., 1998, Shochet et al., 1998). No other prevention programs have addressed both anxiety and depression, nor have they integrated their programs into the school curriculum. The universal Aussie Optimism Program will teach optimistic thinking styles and positive self-talk, self-efficacy, coping strategies and social problem solving to children preparing for their transition to high school. It will be designed in modular format to fit with Australian primary school terms and the K-10 Health and Physical Education curriculum. It is designed to be implemented by teachers, plus a family module will be developed to be used as an adjunct to the classroom program. The program is targeted at a developmental stage just prior to the increase in depression symptomatology in early adolescence. The program has the potential to promote the mental health of children on a larger scale than previous programs, to reduce the incidence of anxiety and depression in young people and to increase their resilience to life's stresses.Read moreRead less