T-follicular Helper Cell Subtypes That Induce Protective Anti-malaria Antibodies
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Malaria causes significant disease burden globally. Currently there are no malarial vaccines that are suitable for widespread use. The development of effective vaccines is hampered by limited understanding of how the human immune system fights malaria. This project will use human samples collected to investigate how human blood cells activate the immune system to fight malaria. This research will identify avenues to improve the design of malaria vaccines in the future.
Investigating Type I Interferon-mediated Immune-suppression During Plasmodium Infection
Funder
National Health and Medical Research Council
Funding Amount
$561,617.00
Summary
Some infections tend to afflict us only once in our lifetimes, for example chickenpox. This is because our bodies develop immunity to these infections relatively easily. The same is not true for malaria. It is thought that our immune systems are somehow suppressed during this disease. This project aims to understand how the immune system is suppressed during malaria infection, in order that we can block this process, and help our bodies fight this disease more effectively.