Cross-bridge cycling-dependent activation of force production in the absence of Ca2+ in fast- and slow-twitch skeletal muscle fibre types. The project will contribute new knowledge about how skeletal muscle works, which will be published in top international journals in biological sciences. This will increase the reputation of Australian science in muscle research and will have the potential to benefit Australian people and Australian athletes. The project will also provide several Australian re ....Cross-bridge cycling-dependent activation of force production in the absence of Ca2+ in fast- and slow-twitch skeletal muscle fibre types. The project will contribute new knowledge about how skeletal muscle works, which will be published in top international journals in biological sciences. This will increase the reputation of Australian science in muscle research and will have the potential to benefit Australian people and Australian athletes. The project will also provide several Australian research students the opportunity to develop sophisticated laboratory and reasoning skills.Read moreRead less
Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
A molecular structure-function investigation of major membrane channels involved in olfactory transduction. Olfactory receptor neurons are extraordinarily-sensitive sensors for detecting minute concentrations of odorant molecules. This project aims to extend our previous studies of these specialised mammalian olfactory cells by using state-of-the art technologies: electrophysiology (patch-clamp) and molecular biology (site-directed-mutagenesis), to investigate how the molecular structure of the ....A molecular structure-function investigation of major membrane channels involved in olfactory transduction. Olfactory receptor neurons are extraordinarily-sensitive sensors for detecting minute concentrations of odorant molecules. This project aims to extend our previous studies of these specialised mammalian olfactory cells by using state-of-the art technologies: electrophysiology (patch-clamp) and molecular biology (site-directed-mutagenesis), to investigate how the molecular structure of their ion channels (selective protein pores) and receptors contribute to the odorant-induced generation of electrical activity, which mediates our sense of smell (olfaction). The project has specific relevance for understanding olfaction, as well as relevance for other sensory systems and other ion channels.Read moreRead less
SKELETAL MUSCLE: REVERSIBLE TEMEPERATURE-INDUCED UNCOUPLING OF CONTRACTION FROM THE ACTIVATOR Ca2+ AND TUBULAR SYSTEM ROLES IN MUSCLE FUNCTION REGULATION. Skeletal muscles represent the largest organ in the body of vertebrates and are responsible for major functions including maintaining posture and locomotion. Skeletal muscles are also a major source of heat production. The project focuses on temperature-induced effects on the ability of the skeletal muscle to contract in warm blooded animals, ....SKELETAL MUSCLE: REVERSIBLE TEMEPERATURE-INDUCED UNCOUPLING OF CONTRACTION FROM THE ACTIVATOR Ca2+ AND TUBULAR SYSTEM ROLES IN MUSCLE FUNCTION REGULATION. Skeletal muscles represent the largest organ in the body of vertebrates and are responsible for major functions including maintaining posture and locomotion. Skeletal muscles are also a major source of heat production. The project focuses on temperature-induced effects on the ability of the skeletal muscle to contract in warm blooded animals, including marsupials, and on the complex roles played by a cellular structure unique to the muscle fibre, the tubular system, with respect to regulation of muscle function at physiological temperatures. The project will test hypotheses that will have far-reaching implications for muscle physiology, cell biology and evolutionary biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989782
Funder
Australian Research Council
Funding Amount
$524,000.00
Summary
A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria t ....A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria to better understand and reduce bacterial infection will result in improvements in human health. Sorting parasites, bacteria and immune cells will lead to new animal vaccines for parasites and diseases such as bird flu. Sorting marine plankton will lead to more sustainable marine ecosystems and fisheries.Read moreRead less
Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental condition ....Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental conditions (especially exposure to steroid-like pollutants) is crucial to support breeding programs of endangered species and may improve veterinary and medicinal treatment of premature animals and humans. This multi-disciplinary, international collaboration provides an international training ground and two-way exchange of students and postdocs.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347278
Funder
Australian Research Council
Funding Amount
$383,000.00
Summary
Brain Slice Macroscopic Imaging and Electrophysiology Recording System. Electrical signals are the primary mode of communication between excitable cells, in particular, the cells (neurons) that comprise the brain and central nervous system. Understanding of the processes of cell-to-cell communication between neurons is of primary importance to our understanding of fundamental phenomena such as voluntary and reflex movement, sensory responses and learning and memory, as well as providing fundamen ....Brain Slice Macroscopic Imaging and Electrophysiology Recording System. Electrical signals are the primary mode of communication between excitable cells, in particular, the cells (neurons) that comprise the brain and central nervous system. Understanding of the processes of cell-to-cell communication between neurons is of primary importance to our understanding of fundamental phenomena such as voluntary and reflex movement, sensory responses and learning and memory, as well as providing fundamental knowledge of numerous disease states. We are applying for equipment to monitor electrical signals (both visually and electrically) of small groups of cells (neurons) or large groups of interconnected cells (macroscopic complexes) within the brain. Facilities of this type for the visual and electrical recording of cell communication and brain activity will be unique to these Universities in Australia and extremely rare in the scientific world.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less