Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifes ....Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifest at present and future high-energy colliders and gravitational wave observatories. Read moreRead less
New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the con ....New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the construction of new theories that deepen our understanding of elementary particles and their interactions. This should provide significant benefits to intellectual culture and the training of early-career researchers as flexible problem solvers able to innovate in any context in industry or government service.Read moreRead less
High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high- ....High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high-energy experiments. This project will satisfy that role. The application of particle detector expertise to state-of-the-art X-ray imaging detectors for the Australian Synchrotron and medical imaging is a perfect example of fundamental science tools applied to other fields. Australian Synchrotron experiments stand to gain much.Read moreRead less
Frontier Experiments in High Energy Physics. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the mo ....Frontier Experiments in High Energy Physics. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter?
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Frontier Experiments in High Energy Physics. This project will support physicists in the expected era of discovery in the knowledge of fundamental particles that makes up our Universe. Having participated in developing the giant $½ billion ATLAS experiment, Australian scientists will be making major discoveries in this era. ATLAS will hunt down the Higgs boson, to understand the origin of mass of fundamental particles. It will also search for particles to explain Dark Matter, which makes up 25% ....Frontier Experiments in High Energy Physics. This project will support physicists in the expected era of discovery in the knowledge of fundamental particles that makes up our Universe. Having participated in developing the giant $½ billion ATLAS experiment, Australian scientists will be making major discoveries in this era. ATLAS will hunt down the Higgs boson, to understand the origin of mass of fundamental particles. It will also search for particles to explain Dark Matter, which makes up 25% of our Universe. ATLAS will search for undiscovered laws of nature to help us unify our understanding of the forces of nature. Excellent training and enhhancement of public interest, international cooperation and networking, and national pride will be provided by this project.Read moreRead less
New generation pulsed magnetron sputtering for the synthesis of advanced materials. Magnetron sputtering underpins the manufacture of many products ranging from semiconductor microelectronics to energy efficient windows. This project will create a new generation sputtering process fully compatible with current technology but capable of synthesising new phases and new film microstructures with greatly enhanced performance.
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Regulation of Stress Hormone Receptors in the Brain. Our research will provide information on how the brain controls our response to stress and will allow the development of targeted strategies to reduce the possibility during chronic stress of the development of conditions such as anxiety and depression. This will improve mental health outcomes in Australia and add to Australia's economic and social stability.
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered i ....Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.Read moreRead less