Rapid mapping of genes for complex traits. This project will develop a new resource that will allow rapid identification of genes controlling complex traits. This world-leading resource will improve knowledge of diseases like diabetes and neurological diseases.
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.
Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to ....Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to accelerate breeding for diverse production environments, with direct applications in barley, and other major cereals including wheat and oats. This should provide significant economic and social benefits to the Australian grains industry through yield stability amidst climate variability.Read moreRead less
Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which in ....Precise frequency generation for testing fundamental physics and developing new devices. Precision microwave oscillators developed in Australia and France have applications in telecommunications, advanced radar, optical to microwave links, frequency and time standards, tests of fundamental physics etc. This project will aid in the transfer of new knowledge between France and Australia and strengthen Australian 'know how' and expertise, essential for the timely development of technology, which includes devices for the European Space Agency's Atomic Clock Ensemble in Space mission, which is due for launch in 2010. This project highlights the importance of Australian Science in a high profile international mission.Read moreRead less
Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water e ....Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water exchange between lagoons and open sea, effects of contaminant spills and recruitment within the reef systems. An understanding of these processes is essential for the sustainable management of these systems.Read moreRead less
Microwave Frequency Standards: Testing Fundamental Physics and Developing New Devices. Highly frequency stable oscillators may be used as frequency or timing standards (clocks) and have commercial application as well as application of testing fundamental physical principles. This project is to continue the development of novel frequency standards in collaboration with some of the best research institutes in France funded by the French Space Agency (CNES). With the advent of the International Spa ....Microwave Frequency Standards: Testing Fundamental Physics and Developing New Devices. Highly frequency stable oscillators may be used as frequency or timing standards (clocks) and have commercial application as well as application of testing fundamental physical principles. This project is to continue the development of novel frequency standards in collaboration with some of the best research institutes in France funded by the French Space Agency (CNES). With the advent of the International Space Station and new atomic clocks, the physics community is embarking on an experimental program that will make use of the microgravity environment of space. Combined with the new improved timing it will be possible to perform new experimental tests of general and special relativity, tests for drifts in the fine structure constant and tests for a preferred direction of the speed of light at unprecedented sensitivity.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized ele ....The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized electrodes in biological media, especially single cells and minute samples in biology and forensic science, etc. Extensive use of neutron characterization techniques aligns strongly this project with the new OPAL reactor to be commissioned in 2007.Read moreRead less
Probing the internal contacts of all solid-state polymeric ion sensors. The results of this research will enable the development of robust and reliable all solid-state polymeric ion sensors. These sensors will enable solutions to significant environmental problems such as soil salinity and acidity, and may pave the way for new and exciting analytical applications, e.g., miniaturized implantable sensors for in-vivo use, microfluidics and Forensic Science, single blood droplet clinical analyzers, ....Probing the internal contacts of all solid-state polymeric ion sensors. The results of this research will enable the development of robust and reliable all solid-state polymeric ion sensors. These sensors will enable solutions to significant environmental problems such as soil salinity and acidity, and may pave the way for new and exciting analytical applications, e.g., miniaturized implantable sensors for in-vivo use, microfluidics and Forensic Science, single blood droplet clinical analyzers, rugged solid contact ion sensors for use in submersible oceanographic analyzers, etc. The research will develop a unique in-situ neutron reflectometry technique for the study of electrochemical interfaces, providing scientific opportunities for the new Australian Replacement Research Reactor.Read moreRead less