Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
Active Ice-Shelf Rift Systems on the Amery Ice Shelf, East Antarctica. Our work will inform the public on how the Antarctic might contribute to global sea level rise, e.g., are current iceberg production rates accelerating and causing inland ice to flow into the sea more rapidly? Furthermore, a greater understanding of the important Earth systems, including the ocean-ice-atmosphere system, is important to a society contemplating the responsibilities of stewardship of the planet as we move into t ....Active Ice-Shelf Rift Systems on the Amery Ice Shelf, East Antarctica. Our work will inform the public on how the Antarctic might contribute to global sea level rise, e.g., are current iceberg production rates accelerating and causing inland ice to flow into the sea more rapidly? Furthermore, a greater understanding of the important Earth systems, including the ocean-ice-atmosphere system, is important to a society contemplating the responsibilities of stewardship of the planet as we move into the era of potentially profound effects from global climate change.Read moreRead less
Southern Ocean productivity and carbon dioxide (CO2) exchange under current and future climate regimes. This project will contribute to Australian ocean science expertise in key areas of data synthesis, satellite oceanography and the understanding of marine ecosystems' response to climate change. Collaborations will be developed and strengthened among Australian research institutions, and between Australia and the United States. The focus of the research is the Southern Ocean, which impacts glob ....Southern Ocean productivity and carbon dioxide (CO2) exchange under current and future climate regimes. This project will contribute to Australian ocean science expertise in key areas of data synthesis, satellite oceanography and the understanding of marine ecosystems' response to climate change. Collaborations will be developed and strengthened among Australian research institutions, and between Australia and the United States. The focus of the research is the Southern Ocean, which impacts global climate, and on which Australia's southern coastal ecosystems depend. The expertise and techniques developed will have application to other Australian regional seas.Read moreRead less
Assessment of the potential consequences of large-scale eradication of rice grass from the Tamar Estuary, Tasmania. Introduced Rice grass has trapped large volumes of intertidal sediment, yet reduced amenity values of the Tamar Estuary, transforming beaches into muddy rice grass meadows, threatening aquaculture industries, and silting up coastal developments. This project will investigate the consequences of rice grass eradication, by determination of sediment volume trapped, contaminants contai ....Assessment of the potential consequences of large-scale eradication of rice grass from the Tamar Estuary, Tasmania. Introduced Rice grass has trapped large volumes of intertidal sediment, yet reduced amenity values of the Tamar Estuary, transforming beaches into muddy rice grass meadows, threatening aquaculture industries, and silting up coastal developments. This project will investigate the consequences of rice grass eradication, by determination of sediment volume trapped, contaminants contained, and monitoring of processes active after removal. The outcomes of this research will enable informed decisions on management of the Tamar rice grass infestation, and provide an understanding the impacts of large scale eradication to management authorities of similar infestations in Victoria, New Zealand, Europe, China and the USA.Read moreRead less
A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of import ....A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of important organic reactions and enhancing collaboration nationally and internationally between computational and synthetic chemists. This should provide significant benefits in the form of improved chemical reactions for chemists to prepare new pharmaceuticals, agrochemicals and materials.Read moreRead less
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100937
Funder
Australian Research Council
Funding Amount
$373,484.00
Summary
Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this u ....Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this understanding into a state-of-the-art climate model to study mixing impacts on the ocean circulation and climate. This project aims to produce substantial improvements in climate models and allow Australia to predict and respond more effectively to climate change.Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less