Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0221983
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laborat ....Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laboratory will also act as a facility for undertaking consulting projects with industry groups by the applicants.Read moreRead less
Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an ex ....Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an excellent postgraduate training environment, it aims to provide and develop, in partnership with industry, optimum zirconium alloying and grain refinement technology with ZirCAST and enhance Australia's leading global position in this strategically and commercially important area.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560828
Funder
Australian Research Council
Funding Amount
$363,288.00
Summary
Hydrodynamics and water quality field research facility. Understanding the fate of sediments and contaminants transported through catchments and the marine environment and their impacts on aquatic and marine ecosystems requires detailed hydrodynamic understanding at a range of scales. By establishing a state of the art research facility, JCU and GU together have a unique opportunity to provide hydrodynamic and water quality research which will support research priority areas of both institutions ....Hydrodynamics and water quality field research facility. Understanding the fate of sediments and contaminants transported through catchments and the marine environment and their impacts on aquatic and marine ecosystems requires detailed hydrodynamic understanding at a range of scales. By establishing a state of the art research facility, JCU and GU together have a unique opportunity to provide hydrodynamic and water quality research which will support research priority areas of both institutions, and advance the understanding of Australia's important tropical and subtropical ecosystems. Currently, excellent researchers and novel collaborations between and within James Cook University and Griffith University, are restricted by the lack of essential modern equipment.Read moreRead less
Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water e ....Hydrodynamics of Fringing Reef Systems. This project aims to develop a numerical circulation model applicable to fringing reef systems, in particular, the Ningaloo reef, Western Australia. The model will include the effects of tides, winds, surface gravity waves and density. The model results will be compared to field measurements collected by the Australian Institute of Marine Science. After the model has been developed and validated, it will be used to investigate processes such as water exchange between lagoons and open sea, effects of contaminant spills and recruitment within the reef systems. An understanding of these processes is essential for the sustainable management of these systems.Read moreRead less
Modelling and characterisation of radiation beams used in radiotherapy. The purpose of this project is to use computer modelling of radiation fields in radiotherapy to investigate and improve their precision. It is expected that this will result in improved outcomes and fewer side-effects for radiotherapy patients.
Mobility of water in cartilage as a probe of molecular structure and function. Clinical diagnosis of early-stage osteoarthritis is difficult, and most patients are not diagnosed until a substantial degradation of cartilage has occurred as a result of the disease. This research will study the interaction between different components of articular cartilage and investigate, how this interaction can be exploited for the development of reliable and non-invasive techniques of cartilage imaging. Mobili ....Mobility of water in cartilage as a probe of molecular structure and function. Clinical diagnosis of early-stage osteoarthritis is difficult, and most patients are not diagnosed until a substantial degradation of cartilage has occurred as a result of the disease. This research will study the interaction between different components of articular cartilage and investigate, how this interaction can be exploited for the development of reliable and non-invasive techniques of cartilage imaging. Mobility of water molecules is a potent indicator of the microscopic structure of the cartilage scaffold. We will use this fundamental biophysical relationship to measure the internal architecture of collagen fibres; observe the changes effected by mechanical load; and distinguish between healthy and osteoarthritic cartilage.
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Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscie ....Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscience, brain imaging technology and fMRI analysis software.Read moreRead less
Promoting transition metal complex catalysis with plasmonic antennae. This project aims to apply visible light photocatalysis to a wide range of chemical reactions by utilizing the intriguing effects of intense light absorption by plasmonic metal nanoparticles, such as generating energetic electrons, changing reactant adsorption and the chemical binding of reactant with the catalyst. These effects will promote catalysis at surface-bound metal complex reaction sites under mild reaction conditions ....Promoting transition metal complex catalysis with plasmonic antennae. This project aims to apply visible light photocatalysis to a wide range of chemical reactions by utilizing the intriguing effects of intense light absorption by plasmonic metal nanoparticles, such as generating energetic electrons, changing reactant adsorption and the chemical binding of reactant with the catalyst. These effects will promote catalysis at surface-bound metal complex reaction sites under mild reaction conditions. This is a part of our long-term effort to transform chemical production by heating into green photocatalytic process. This project expects to generate knowledge crucial for developing theories for catalysis, the design of efficient catalysts, green chemical synthesis methods, and enhance international collaboration.Read moreRead less
Measuring the flushing time of waters in the Great Barrier Reef. There are concerns both in the scientific community and in the general public about the possible implications of agricultural runoff to the Great Barrier Reef (GBR). Due to this, the Great Barrier Reef Marine Park Authority has developed a "Reef Water Quality Protection Plan" (RWQPP) which may have significant economic implications to the grazing, sugar, and other primary industries. In order to protect the GBR, whilst also minimiz ....Measuring the flushing time of waters in the Great Barrier Reef. There are concerns both in the scientific community and in the general public about the possible implications of agricultural runoff to the Great Barrier Reef (GBR). Due to this, the Great Barrier Reef Marine Park Authority has developed a "Reef Water Quality Protection Plan" (RWQPP) which may have significant economic implications to the grazing, sugar, and other primary industries. In order to protect the GBR, whilst also minimizing the impacts on agricultural industries, it is important to understand the processes that affect the buildup and broad-scale dispersion of contaminants in the GBR. This project will facilitate that understanding.Read moreRead less