Lipid Trafficking At Membrane Contact Sites: The Role Of Oxysterol-Binding Protein-Related Protein 5 And 8 (ORP5 And ORP8)
Funder
National Health and Medical Research Council
Funding Amount
$466,400.00
Summary
Abnormal subcellular lipid distribution is associated with a number of common diseases including cancer, cardiovascular disease, and Alzheimer’s disease. The overall aim of this proposal is to identify and characterize new molecules that regulate the transport of lipids between different cell membranes. Results from the proposed studies will help developing novel therapeutic agents against common human diseases.
Targeting Phosphoinositide Metabolism In Leishmania
Funder
National Health and Medical Research Council
Funding Amount
$990,904.00
Summary
There is an urgent need to develop new drugs to treat human leishmaniasis, a disease that causes debilitating and life-threatening diseases in millions of people worldwide. This project will investigate whether it is possible to develop a new generation of drugs that target an important signaling pathway in these parasites that we have shown to be essential for virulence
A New Signaling Interface Shapes Cystic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$586,846.00
Summary
This grant investigates the previously uncharacterised association between the INPP5E and AURKA proteins. Both are involved in cell signaling and the development of cystic kidney disease. We will study the nature of this interaction and investigate whether it is possible to ameliorate kidney disease by inhibiting their actions in the developing and adult kidney.