Phosphatase Regulators Mediate Long-term Changes In Presynaptic Terminals
Funder
National Health and Medical Research Council
Funding Amount
$984,163.00
Summary
The strength of communication between each nerve cell in the brain depends on how active that nerve cell has been. This enables the brain to be adaptable and is a way for the brain to set up circuits that underlie how we learn and remember. More or less release of chemical messengers (neurotransmitters) into nerve cell junctions changes the strength of nerve cell communication. We have discovered a new chemical signalling pathway controlling neurotransmitter release.
Cardiovascular Effects Of Enhanced Leptin Signalling
Funder
National Health and Medical Research Council
Funding Amount
$1,200,972.00
Summary
Leptin treatment causes weight loss, but leptin also increases blood pressure. We wish to determine if increasing leptin signalling, by modifying signal transduction pathways within leptin sensitive cells in the brain, can reduce weight without increasing blood pressure.
Dissecting PTEN-regulated Pathways In The Genesis Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$302,981.00
Summary
Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The PTEN phosphatase is one of the most common targets for inactivation in melanoma. The precise role of PTEN and its contribution to melanoma development have not been thoroughly explored. This work will highlight potentially novel pathways and molecules that are likely to be critical in the genesis of melanoma and to the ratio ....Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The PTEN phosphatase is one of the most common targets for inactivation in melanoma. The precise role of PTEN and its contribution to melanoma development have not been thoroughly explored. This work will highlight potentially novel pathways and molecules that are likely to be critical in the genesis of melanoma and to the rational approach to targeted therapy.Read moreRead less
Phosphoinositide 4-phosphatases In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$678,560.00
Summary
This project aims to understand the structure and function of an important group of signalling enzymes involved in the development of cancers such as melanoma.