Synthesis of Novel Biomaterials for Drug delivery. A new UV radiation polymerisation technique utilising charge-transfer complexes is adopted for synthesising novel hydrogels, a group of biomaterials for drug delivery. This work is significant as charge-transfer complexes, pertinent to the formation of hydrogels, form copolymers within the hydrogel matrices. This eliminates using costly, yet undesirable photo-initiators (PI), thus rendering the hydrogels as cleaner (PI-free) and more economical ....Synthesis of Novel Biomaterials for Drug delivery. A new UV radiation polymerisation technique utilising charge-transfer complexes is adopted for synthesising novel hydrogels, a group of biomaterials for drug delivery. This work is significant as charge-transfer complexes, pertinent to the formation of hydrogels, form copolymers within the hydrogel matrices. This eliminates using costly, yet undesirable photo-initiators (PI), thus rendering the hydrogels as cleaner (PI-free) and more economical in production; the products present themselves as ideal treatment methods in the controlled-release of drugs, specifically targeting localised pathological sites of interest. The research findings will be invaluable to medical practices, leading to the creation of new industries in Australia.
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Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestin ....Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestine when the polymer is dissolved. Particle size control is feasible by dense gas processes by manipulating operating parameters. Advantages include low residual solvent and manufacture at ambient temperatures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101666
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Endogenous bone regenerative technique to repair hard tissue defects in congenital craniofacial clefts. This project aims to develop an endogenous bone regenerative technique to repair the bony defects in congenital craniofacial clefts, through stimulating patients' latent self-repair mechanisms and reviving their innate capacity for regeneration. The novel technique would replace the existing and controversial surgical bone grafting method.
Drug Delivery Devices : Hydrogels manufactured utilising Dense Gas Technologies. Many drugs are rapidly eliminated from the human body, and would benefit from being released over a long period of time. In this study, formulations to deliver drugs will be developed, using hydrogels: highly cross-linked, water saturated polymers. The polymers to be investigated are based on ingredients suitable for ingestion. Hydrogels are in common use as external therapeutic devices, such as contact lenses or wo ....Drug Delivery Devices : Hydrogels manufactured utilising Dense Gas Technologies. Many drugs are rapidly eliminated from the human body, and would benefit from being released over a long period of time. In this study, formulations to deliver drugs will be developed, using hydrogels: highly cross-linked, water saturated polymers. The polymers to be investigated are based on ingredients suitable for ingestion. Hydrogels are in common use as external therapeutic devices, such as contact lenses or wound dressings. However, hydrogels are not commonly in use as ingested drug delivery devices due to problems with the existing technologies, such as toxicity of ingredients. These problems will be addressed in this study.Read moreRead less
Carbon Dioxide: Solvent, Carrier and Reagent, for novel polymer networks with controlled nano-architectures. The proposed environmentally friendly technology has broad applications for improving properties of various polymeric matrices used for biomedical applications. The process developed would value-add for manufacturing biomedical polymeric devices in Australia with licensing of existing fabrication methods as a best option. Moreover, the leading-edge polymer technology developed would mini ....Carbon Dioxide: Solvent, Carrier and Reagent, for novel polymer networks with controlled nano-architectures. The proposed environmentally friendly technology has broad applications for improving properties of various polymeric matrices used for biomedical applications. The process developed would value-add for manufacturing biomedical polymeric devices in Australia with licensing of existing fabrication methods as a best option. Moreover, the leading-edge polymer technology developed would minimise the organic solvent consumption and will attract business from international polymer and biotechnology companies for production of implant and drug delivery devices. The development of world-class research provides Australia with recognition as a world leader in the field and broadens the knowledge based of Australian scientist and engineers.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less