Precision Medicine For Epilepsy And Beyond: From Discovery To Implementation And Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$487,891.00
Summary
The theme of this Fellowship is to improve treatment outcomes using a genomic-based Precision Medicine approach. This goal will be achieved by 3 closely linked projects that harness the power of gene sequencing and advances in biosensor technology, coupled with careful clinical and health economic evaluation. While the emphasis is on epilepsy, the research will extend to other major disease areas of global health significance. The potential socioeconomic impact of these innovations is enormous.
Genomics Of Antiepileptic Drug-induced Stevens Johnson Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$500,817.00
Summary
Epilepsy affects 3% of people. Severe skin reactions to anti-epileptic drugs are unpredictable and potentially fatal. This project aims to better understand the complex genetic architecture of these reactions using the latest sequencing platforms applied to a unique collection of samples, followed by functional analysis. The findings will enhance the practice of precision medicine in epilepsy treatment, shed light on the mechanisms of these reactions, and inform better drug design in the future.