Defining Targets For Antifungal Stewardship In Immunocompromised Patients: Optimising Care And Safety
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
Patients with impaired immune systems are at risk of serious fungal infections. Antifungal medicines used to prevent and treat these infections can be toxic and costly. This project aims to review current antifungal use and improvement activities in place in health services, assess prescriber knowledge, and to evaluate current doses of echinocandin antifungals used in liver failure patients. This project will identify ways to improve antifungal use needed for effective and safe prescribing.
Optimisation Of Antimicrobial Therapy For Severe Bacterial Infections In Neonates And Young Children In Papua New Guinea
Funder
National Health and Medical Research Council
Funding Amount
$943,865.00
Summary
This study aims to provide important information on the way young Papua New Guinean children with serious bacterial infections handle antibiotics, including newer agents that may be required if bacterial resistance is confirmed or increases. The data will be used to optimise treatment, thus reducing mortality and potential adverse drug effects, in PNG nad other tropical countries, and may have implications for the developed world as well.
A Prospective, Randomised, Double-blind Trial Of Extended- Versus Bolus-infusion ?-lactam Therapy In Infective Exacerbations Of Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$148,431.00
Summary
I am an infectious diseases physician focused on the most effective way to use antibiotics to treat infections. People with cystic fibrosis often get lung infections and the bacteria that causes this, Pseudomonas aeruginosa, can be difficult to treat. I will be investigating whether infusing antibiotics over a prolonged period of time is more effective than standard therapy in treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.