Targeting The Unmet Global Medical Need Caused By Gram-negative 'superbugs': From Antibiotic Discovery To Novel Therapeutic Strategies
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Bacterial ‘superbugs’ present a significant global medical challenge. ‘Old’ polymyxins are the only antibiotics against Gram-negative ‘superbugs’ but with limited pharmacological information available. In the next 5 years, as a pharmacologist I will continue re-developing polymyxins and discovering novel antibiotics against these problematic bacteria. My research targets the “Bad Bugs, No Drugs” disaster highlighted by the Infectious Diseases Society of America and the World Health Organization.
Senior Research Fellowship In Lipoprotein Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
A physiologist describing metabolic pathways and mechanisms that regulate lipoprotein metabolism in in vitro and in vivo systems. My research uses complex tracer studies and mathematical modelling to identify and quantitate pathways of lipid metabolism in normal and diseased states prior to and following lifestyle and/or pharmacological interventions. The focus of my research is on cardiovascular disease risk reduction.