Role Of Sympathetic Nervous System In The Development Of Early Organ Damage In Obesity:an Emerging Target For Therapy
Funder
National Health and Medical Research Council
Funding Amount
$544,534.00
Summary
Young people with obesity often have no signs of cardiovascular disease but their organs, such as the heart, the kidneys and the blood vessels present early evidence of damage that can, in time, progress to confer cardiovascular risk. This study will look at the potential beneficial effect of a drug, by itself or in association with a low calorie diet, in reversing the progression of organ damage in young obese subjects.
Effectiveness Of A Skill-building And Price Reduction Intervention For Promoting Healthy Eating
Funder
National Health and Medical Research Council
Funding Amount
$489,989.00
Summary
Many Australians consume diets that place them at risk of obesity and ill health. Research is required to identify effective ways of helping people improve their diets. This study will investigate two approaches to doing so: firstly, by providing people with increased skills in budgeting, selecting and preparing healthy foods; and secondly, by reducing the prices of healthier foods.
Obesity, Overweight And Hospitalisation: Identifying Targets For Interventions To Prevent Adverse Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$603,755.00
Summary
Obesity is an important and rapidly increasing health problem, especially in indigenous communities. The proposed project investigates how obesity affects the risk of hospital admission in Indigenous and non-Indigenous Australians, including providing evidence regarding the nature of the hospitalisation, the cost and whether specific groups are at a higher risk of obesity-related hospitalisation. In doing so it aims to identify targets for intervention to reduce obesity-related hospitalisation
Reconceptualising Health Promotion: The Role Of Values, Ethics And Evidence In Obesity Intervention.
Funder
National Health and Medical Research Council
Funding Amount
$485,103.00
Summary
Obesity and overweight are public health priorities. Population-level programs, campaigns and regulations are required to prevent and reduce obesity. How should these interventions proceed? What is effective? What is ethical? How can we avoid doing harm? At present, we do not know. By studying current interventions in detail, and working with experts and practitioners in health promotion and ethics, this project will develop a new framework to guide overweight and obesity intervention in future.
Prader-Willi Syndrome (PWS) is characterised by symptoms such as obsessions, overeating, rage attacks, skin picking, irregular sleep breathing and temperature control, and impairments in learning and understanding social cues. Evidence from brain studies suggest that such symptoms maybe related to a deficiency of oxytocin, a natural occurring hormone derived in the hypothalamus. This study aims to investigate the efficacy of oxytocin nasal spray on improving behaviour and physical health in PWS.
This study combines sophisticated molecular techniques with state-of-the-art biochemical and physiological analyses to determine how gut hormones regulate satiety. By utilising unique conditional and germline KO mice , this research will make highly original and internationally competitive contributions to the understanding of the regulation of satiety and energy expenditure. Knowledge as to the causes of lack of satiety will be of great benefit in the search for novel treatments for obesity.
A Dietary Intervention In Gestational Diabetes To Reduce Child Obesity: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$354,715.00
Summary
Women with gestational diabetes (GDM) whose blood glucose levels (BGL) are not well controlled have a higher chance of giving birth to large babies. These babies are at high risk of becoming overweight children and adults. Preventing child obesity therefore requires appropriate intervention during pregnancy complicated with GDM. This study will determine the ability of specific dietary advice (aimed at reducing maternal BGL) to reduce the risk of large babies in a typical ante-natal setting.
Testing The Behavioural And Psychosocial Mechanisms Underlying Geographic Variation In Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$415,457.00
Summary
This study seeks to assess the mechanisms that explain the link between residential area features and the metabolic syndrome (obesity and high blood pressure, lipids and glucose), related to cardiometabolic diseases. There is more metabolic syndrome in disadvantaged areas but the reasons for this have not been empirically established. We will evaluate behavioural and psychosocialmechanisms that might independently and jointly explain the association between place and metabolic syndrome.
Efficacy Of Exercise Physiologist Counselling In Primary Care Patients: A RCT Of Two Pragmatic Approaches
Funder
National Health and Medical Research Council
Funding Amount
$940,925.00
Summary
Physical activity is one of the most powerful contributors to health, but population levels of activity are low. General practitioners (GPs) are well placed to provide physical activity counselling, but many are too busy. This project examines the effectiveness of referral of insufficiently active adults to an exercise physiologist (EP), using step counts from a pedometer as the outcome. We compare usual care from the GP with: (1) 5 EP visits, and (2) a single visit and telephone follow up.