Mutational Signatures Of DDT: The Role Of A Controversial Persistent Endocrine Disrupting Pollutant On Prostate Cancer Aetiology
Funder
National Health and Medical Research Council
Funding Amount
$991,000.00
Summary
No carcinogen or prevention has been identified for prostate cancer (PCa). As carcinogens are commonly mutagens, we will use genomic interrogation to determine if extensive use of the hormone-disrupting pesticide DDT during the 40's to late 80's increased PCa globally. Having access to prostate tumours from men with biochemically confirmed lifelong DDT-exposure, will provide a measurable genomic signature to evaluate the impact of DDT globally, including Australia.
Neuromuscular Junction Toxicity After Anticholinesterase Pesticide Poisoning And Envenomation.
Funder
National Health and Medical Research Council
Funding Amount
$1,351,392.00
Summary
The study builds on strong existing NHMRC funded collaborative research links between Sri Lanka and Australia in research which have reduced mortality and provided better evidence for treatment of pesticide poisoning. We will study the paralysing effects of acute insecticide poisoning and snakebite on the human nervous system. We aim to determine whether these can be predicted early in the course of the illness and the long term effects. We also aim to see if any particular insecticides cause mo ....The study builds on strong existing NHMRC funded collaborative research links between Sri Lanka and Australia in research which have reduced mortality and provided better evidence for treatment of pesticide poisoning. We will study the paralysing effects of acute insecticide poisoning and snakebite on the human nervous system. We aim to determine whether these can be predicted early in the course of the illness and the long term effects. We also aim to see if any particular insecticides cause more problems than others.Read moreRead less