Mechanisms Of Escape From Progesterone-induced Suppression: Role In Normal And Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Prematurity caused by preterm birth is the leading cause of death and disease among newborns in Australia. Here we will define how the length of pregnancy is determined by the opposing actions of progesterone, which maintains pregnancy, and prostaglandins, which induce labour. We will demonstrate the mechanism by which the actions of the two hormones are balanced in normal pregnancy and disrupted in preterm labour. We will show that preterm birth can be prevented by correcting the disorder.
The Role Of The Intrauterine (pro) Renin-(pro)renin Receptor System In Prostaglandin Synthesis In Pregnancy.
Funder
National Health and Medical Research Council
Funding Amount
$488,478.00
Summary
Preterm birth is associated with a very high incidence of infant disability and mortality. This has long term economic and social costs to the Australian people. We will demonstrate that in late gestation, the intrauterine (pro)renin renin receptor system controls prostaglandin synthesis by the fetal membranes and the placenta. Prostaglandins can cause premature labour.
Economic impact and policy implications of assisted reproductive technologies in Australia. Assisted reproductive technology (ART) is now a large scale economic activity in Australia, provided almost exclusively by private clinics. The outcome of ART programs, involving the birth of one in 30 children, has a profound effect on the health of the nation. Policy and funding frameworks influence how ART is practiced and the subsequent health outcomes of ART children, yet there is a lack of evidence ....Economic impact and policy implications of assisted reproductive technologies in Australia. Assisted reproductive technology (ART) is now a large scale economic activity in Australia, provided almost exclusively by private clinics. The outcome of ART programs, involving the birth of one in 30 children, has a profound effect on the health of the nation. Policy and funding frameworks influence how ART is practiced and the subsequent health outcomes of ART children, yet there is a lack of evidence to guide government and providers about effective, equitable and safe approaches to funding ART. This research will address that need, thereby fostering a healthy start to life and preventative healthcare; supporting the National Research Priority, promoting and maintaining good health, for ART children, their families and the community.Read moreRead less