Regulation Of Amyloid-beta Production By Glycosphingolipid Synthesis Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$549,925.00
Summary
Alzheimer's disease (AD) prevalence is rising and there is currently no curative treatment. Production of neurotoxic amyloid-beta peptide (Abeta) in the brain is thought to be one causative factor in AD. We have recently discovered a new drug that alters lipid levels in cell membranes and potently inhibits Abeta production by neurons. We will define precisely how this drug works and examine its potential to reduce Abeta accumulation in the brains of mice genetically engineered to mimic AD.
Role Of ABCA-G Transporters In Neuronal Cholesterol Regulation And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$557,582.00
Summary
Alzheimer's disease (AD) prevalence is rising and the contributing factors are poorly understood. Recent research shows that cholesterol regulates the production of neurotoxic amyloid-beta peptide (Abeta). We will study a class of proteins, ABC transporters, that we believe regulate neuronal cholesterol and Abeta metabolism. We will use isolated brain cells, human brain tissue and genetically engineered mice in order to define how cholesterol influences AD and identify new treatment options.