Breastfeeding In Women With Polycystic Ovarian Syndrome, Gestational Diabetes, And Pre-existing Diabetes: Hormonal Physiology, Breastmilk Composition, Epidemiology And Patient Factors
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Polycystic ovary syndrome and diabetes (pre-existing or gestational) are important conditions in pregnant women. I intend to explore (through major literature reviews and original research) how they influence the production and composition of breastmilk, how this differs from women without the conditions, and impacts on infant health. I also aim to examine reasons for lactation difficulties in these women, both from a hormonal (basic science) perspective and at a broader (population) level.
Centre For Research Excellence In The Evaluation, Management And Health Care Needs Of Polycystic Ovary Syndrome And Related Health Implications
Funder
National Health and Medical Research Council
Funding Amount
$2,595,120.00
Summary
Polycystic Ovary Syndrome is a common condition with major health impacts, affecting one in five young Australian and one in four Indigenous women. This condition has reproductive, metabolic and emotional implications including obesity, infertility, diabetes and poor quality of life. This CRE will bring together a team of collaborative research and translation experts to improve diagnosis, capture vital prevention opportunities, optimise management and improve quality of life.
Polycystic ovary syndrome (PCOS) affects a striking 9-21% of women of reproductive age. PCOS is an important health problem and can affect menstrual cycles, fertility and increase risk of diabetes and mood disorders. There is a lack of longitudinal studies that women with PCOS over time to examine the key determinants of PCOS, long-term impact of obesity and factors contributing to PCOS complications.
Polycystic Ovary Syndrome: Implementation Research Using The Experiences And Perspectives Of Women And Health Professionals To Internationally Translate Guidelines And Evidence Into Practice
Funder
National Health and Medical Research Council
Funding Amount
$695,543.00
Summary
Polycystic ovary syndrome (PCOS) affects up to 1 in 5 women. It is associated with a high risk of obesity, infertility, diabetes, and heart disease. We are updating guidelines for PCOS, yet it is not known how to help women and health professionals use these guidelines. This project will involve women with PCOS and health professionals working together to design high quality resources and link these into clinical care to improve the management of PCOS. This will lead to improved health outcomes.
Weight Gain Prevention In Women With Polycystic Ovary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Obesity increases polycystic ovary syndrome (PCOS) prevalence and severity across metabolic, reproductive and psychological features. Weight management is the recommended first-line PCOS treatment and women with PCOS are at high risk of weight gain, but weight gain prevention program has not been trialled in this group. This study will assess the effect of metformin, a commonly prescribed drug for PCOS, and a low-intensity lifestyle program on weight gain women with PCOS.
This proposal supports a successful, productive mid career researcher to generate new knowledge in priority areas of women' health. Clinical, public health, health services and implementation research focuses on prevention and treatment of lifestyles/obesity related conditions across the lifespan. Activities include mentoring young researchers/ clinicians, leadership and collaboration, cross sector engagement and translation of research into practice delivering improved health outcomes.
Polycystic ovary syndrome (PCOS) affects 5-10% of women worldwide, yet its origins remain unknown. Androgens are implicated in the development of PCOS, but the decisive, invasive studies needed to confirm and elucidate their roles are not feasible in women. Hence, using our innovative mouse models of androgen resistant female mice, this study will determine the role of androgens in PCOS aiming to better understand, and identify new treatments for this common female reproductive disorder.