Mechanisms Underlying The Generation Of Spontaneous Contractions In Human Uterine Muscle: Potential Therapeutic Target For Dysfunctional Labour
Funder
National Health and Medical Research Council
Funding Amount
$496,901.00
Summary
Successful labour outcome is critical for the health of mother and offspring. Contractions too soon, or when they fail during labour, have significant short and long term consequences for mother and baby. Our recent studies on tissue from women in labour suggested new possible mechanisms underlying the initiation of uterine contractions. We will now test these ideas with a view to identifying new therapeutic targets for manipulating labour contractions.
Integrating Biology And Medicine To Develop 3D-structure Guided Drug Design For Treatment Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$978,832.00
Summary
Calcium channel inhibitors are commonly prescribed for the treatment of heart disorders such as angina, hypertension, arrhythmias and hypertrophic heart disease. This class of drugs is one of the leading causes of drug-related fatalities. The impediment to designing better drugs is a lack of understanding of the 3 dimensional (3D) structure of the calcium channel. We will enable for the first time a 3D structure blueprint for the design of safe and highly selective calcium channel therapeutics.