School Versus Community-based Albendazole Deworming For Control Of Soil Transmitted Helminths In School-age Children In The Philippines – A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,336,408.00
Summary
Intestinal parasites are a global health problem. The World Health Organization recommends regular distribution of deworming drugs, targeting school aged children. This is effective for the children receiving the drugs but does not have an impact in the wider community. We aim to determine the best strategy for delivery of deworming drugs, to achieve the maximum benefit both for children and wider community, by directly comparing the benefits of a school-targeted vs a community-mass approach.
Graves’ disease is the most common cause of hyperthyroidism. It leads to long-term impairments in quality of life and has a 40% higher mortality rate compared with the general population. We know surprisingly little about the causes of Graves’ disease. One possible trigger is stressful life events; however, the relationship is yet to be proven. This study will assess whether stressful life events, specifically military deployment, are associated with Graves’ disease.
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Does Environmental Change Drive The Spatiotemporal Transmission Dynamics Of Echinococcus Spp. In Ningxia, China?
Funder
National Health and Medical Research Council
Funding Amount
$654,548.00
Summary
Human echinococcosis is a chronic debilitating disease with a death rate that can exceed 90%. In China it is a major public health issue where recent environmental changes are likely to increase transmission rates, thus increasing the disease burden. This project will assess the impact of these environmental changes on the transmission of this disease over space and time, it will predict where new cases will arise, and determine the best methods for sustainable control and then elimination.
Using An Established Simulation Model To Determine Effective And Cost-effective Interventions To Mitigate Influenza Pandemics And Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$416,353.00
Summary
A novel disease spread and economic model is used to determine the cost-effectiveness of a range of mitigation strategies aimed at a future influenza pandemic. A simulation model generates data on which individuals become ill, morbidity and mortality characteristics, an economic costing model determines optimal interventions.
Preventing Mortality In Adults After Release From Prison: Advancing Global Knowledge Through An International, Individual Participant Data Meta-analysis
Funder
National Health and Medical Research Council
Funding Amount
$613,687.00
Summary
Ex-prisoners are at increased risk of death, but not enough is known about the incidence, timing, causes, context or risk factors for preventable death in this population. In this project we have compiled 18 cohorts of ex-prisoners (total number=1,159,290) and will analyse the data to determine exactly which ex-prisoners are at the greatest risk from what, and when. This new knowledge will inform policy changes to reduce the unnecessary loss of life in this vulnerable population.
InterLACE: International Collaboration For A Life Course Approach To Reproductive Health And Chronic Disease Events
Funder
National Health and Medical Research Council
Funding Amount
$495,965.00
Summary
Cardiovascular disease and diabetes are major chronic diseases among women. This world-leading research combines data from 7 international and 3 Australian studies of womenÍs health. We will investigate the relationship of reproductive health, from menarche to menopause, with the risk of Type 2 diabetes and cardiovascular disease in later life. Findings will support the development of policies and preventive health strategies to reduce the risk of these chronic diseases.
Evaluation Of Long-Term Clinical And Health Service Outcomes Following Coronary Artery Revascularisation In Western Australia: Future Implications
Funder
National Health and Medical Research Council
Funding Amount
$638,412.00
Summary
Heart attacks occur when arteries of the heart become blocked, and current treatment involves unblocking the affected vessel by inserting a stent fed through a leg artery or using bypass surgery. There are different types of stents and whether they offer better outcomes than surgery in the long-term is currently undecided. We will evaluate whether patients who receive stents have better outcomes after 5 years than patients who have surgery, and what the various costs are to the health system.
Risk Factors For Long-term Chronic Disease Events In HIV-positive Persons: The D:A:D Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$925,659.00
Summary
The D:A:D Study is a large, international study assessing risk factors for chronic disease events in HIV-positive patients. We know these events, such as heart attacks and cancers, increase with age. And we also know that these events are more common in HIV-positive people. Over the next five years, D:A:D will assess risk factors for chronic disease events in HIV-positive people as they age, and help optimise patient monitoring and management.
Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.