Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Risk assessment for environmental health in Adelaide based on weather, air pollution and population health outcomes. This is the first systematic assessment of the effect of climate variation and air pollution on population health in an Australian temperate region. It is one of the ARC's research priorities (PG 7: Responding to climate change and variability). The results will provide a more complete picture of association among air pollution, climate variability and population health in Austral ....Risk assessment for environmental health in Adelaide based on weather, air pollution and population health outcomes. This is the first systematic assessment of the effect of climate variation and air pollution on population health in an Australian temperate region. It is one of the ARC's research priorities (PG 7: Responding to climate change and variability). The results will provide a more complete picture of association among air pollution, climate variability and population health in Australia. They will also provide important information to policy-makers and communities for their relevant actions, including changes in resource management systems and the operation of these systems, a range of socioeconomic actions, infrastructure establishment, disaster prevention and emergency events response regulation, and health education and promotion campaigns.Read moreRead less
A Regional Perspective on Work & Family Balance and Changes in Employment Regulation. Work/family balance is a focus of significant attention at the community, national and international level. This project will generate new knowledge about the ways in which employment regulation directly and indirectly impacts on employee work/family balance outcomes within different regional and industry contexts. A growing body of research recognises the linkages between employment regulation and effects on c ....A Regional Perspective on Work & Family Balance and Changes in Employment Regulation. Work/family balance is a focus of significant attention at the community, national and international level. This project will generate new knowledge about the ways in which employment regulation directly and indirectly impacts on employee work/family balance outcomes within different regional and industry contexts. A growing body of research recognises the linkages between employment regulation and effects on child and parent well-being and health, labour force supply and economic outcomes. However, little is known about how geographical location shapes work/family balance. The research will thus contribute to improved understandings and to better social policy at the local, state and federal levels.Read moreRead less
Special Research Initiatives - Grant ID: SR0354804
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impac ....ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impacts of contaminated soil and wastes, and land remediation. By facilitating communication, the network enhances national and international research coordination, interaction with regulators, end-users, industry, and other stakeholders, achievement of critical mass for new initiatives, enhances research training and contributes to a critical National Priority.Read moreRead less
Local government, mining companies and resources development in regional Australia: meeting the governance challenge. Sustainable regional development and continuing growth of the resources sector are key national priorities. The current resources boom is placing significant pressure on the physical, social and governance infrastructure of mining-intensive regions. Unless these issues can be better managed, new resource projects risk being delayed or deferred and the trend to fly-in fly-out oper ....Local government, mining companies and resources development in regional Australia: meeting the governance challenge. Sustainable regional development and continuing growth of the resources sector are key national priorities. The current resources boom is placing significant pressure on the physical, social and governance infrastructure of mining-intensive regions. Unless these issues can be better managed, new resource projects risk being delayed or deferred and the trend to fly-in fly-out operations will be accelerated, with deleterious consequences for sustainable regional growth. This project will contribute to a more effective response to these challenges by investigating the changing nature of local level governance in mining intensive regions and how these arrangements can be improved.Read moreRead less
Taking eDNA underground: transforming assessment of subterranean ecosystems. This project aims to improve Environmental Impact Assessment and monitoring of subterranean ecosystems by developing a rigorous, credible and practicable environmental DNA assessment framework. Resource companies in Western Australia are mandated to assess groundwater biodiversity under Environmental Protection legislation. Current surveys are time-consuming (expensive) and biased toward common taxa. For regulators, sta ....Taking eDNA underground: transforming assessment of subterranean ecosystems. This project aims to improve Environmental Impact Assessment and monitoring of subterranean ecosystems by developing a rigorous, credible and practicable environmental DNA assessment framework. Resource companies in Western Australia are mandated to assess groundwater biodiversity under Environmental Protection legislation. Current surveys are time-consuming (expensive) and biased toward common taxa. For regulators, stakeholders and industry involved in this project we will provide real-world information and cost savings through innovation in understanding patterns in species boundaries and detection of subterranean fauna. The outcomes will be directly applicable to monitoring subterranean ecosystems across Australia and internationally.Read moreRead less
Cycle Aware: Driving with Bikes. This project focuses on the education and training required by drivers to interact safely with cyclists. It uses two ontologically diverse methodologies to examine how Australian drivers become cyclist aware and the education and training necessary to foster safe driver–cyclist interactions. The project aims to provide a critical knowledge base for state and territory driver education policies and a cycle-aware module for learner drivers. These outcomes are inten ....Cycle Aware: Driving with Bikes. This project focuses on the education and training required by drivers to interact safely with cyclists. It uses two ontologically diverse methodologies to examine how Australian drivers become cyclist aware and the education and training necessary to foster safe driver–cyclist interactions. The project aims to provide a critical knowledge base for state and territory driver education policies and a cycle-aware module for learner drivers. These outcomes are intended to reduce cyclist road trauma and on-road tensions between cyclists and drivers, and to improve opportunities for active travel to tackle the growing issue of inactivity.Read moreRead less
Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australi ....Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australians. The project is significant because it adopts a sector-wide view to systematically define social risk, co-create a social risk management framework and implement it via a new social risk management toolkit. This should lessen harm to communities, reduce delays and costs and benefit national infrastructure delivery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less