Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Rates, Patterns And Determinants Of Alcohol’s Harm To Others: A Cross-national Comparative Study
Funder
National Health and Medical Research Council
Funding Amount
$305,856.00
Summary
Alcohol causes harms to drinkers, and others around them, including spouses, children, family, friends, workmates and strangers. Australian and New Zealand work on alcohol’s harm to others is being replicated by the WHO in 7 countries (Chile, Nigeria, Sri Lanka, India, Thailand, Laos and Vietnam). We aim to analyse datasets from nine countries and compare the magnitude and patterning of problems across and within cultures – identifying opportunities for reducing harm from others’ drinking.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniq ....Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniques will be used to elucidate the fundamental mechanisms of gravity current entrainment and propagation. This knowledge will set a strong foundation to improve operational forecasts of smoke transport that will allow government agencies to better respond to the negative impact of these complicated flows.Read moreRead less
Deeper and broader life cycle risk assessment - extending the frontier for hybrid methodologies. This project is about combining detailed and global perspectives of environmental health risk from different fields of planning practice. It aims to improve the depth and breadth of the types of information used by government regulators and the community in decisions about the development of capital works.
Discovery Early Career Researcher Award - Grant ID: DE170101180
Funder
Australian Research Council
Funding Amount
$327,900.00
Summary
Understanding and preventing road deaths using coronial investigations. This project aims to study coronial death investigations of fatal road crashes in Australia using public health and road safety theoretical frameworks. Fatal road crashes are sudden, unexpected and violent. Each fatality has a lasting effect resulting in immeasurable emotional costs and a financial burden in excess of $3.8 billion per year. Intended outcomes will contribute to understanding of fatal road crashes including pr ....Understanding and preventing road deaths using coronial investigations. This project aims to study coronial death investigations of fatal road crashes in Australia using public health and road safety theoretical frameworks. Fatal road crashes are sudden, unexpected and violent. Each fatality has a lasting effect resulting in immeasurable emotional costs and a financial burden in excess of $3.8 billion per year. Intended outcomes will contribute to understanding of fatal road crashes including pre-crash social factors (e.g. alcohol/drug use and dependence, unemployment, age), the use and effect of coronial recommendations on road safety policy and practice, and preventing deaths on Australian roads.Read moreRead less
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100066
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scienti ....Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scientists and analysts from Australia and abroad conducting research projects of national and international significance. In particular, the project would provide policy-makers, investors and communities with detailed and tailored information to help make better decisions about a sustainable future. By upgrading IELab hardware and analytical and modelling software, the project would be versatile and flexible and remain up to date.Read moreRead less
Networks in Flux: Examining how sector relationships adapt to rapid change. This study aims to investigate why, when and how inter-organisational networks adapt or remain resistant to change. Responding to complex social problems and technological change requires inter-organisational networks to be adaptable. Through a combination of longitudinal network analysis, survey research and qualitative interviews, this project plans to study the Victorian HIV and hepatitis C sector as it responds to ma ....Networks in Flux: Examining how sector relationships adapt to rapid change. This study aims to investigate why, when and how inter-organisational networks adapt or remain resistant to change. Responding to complex social problems and technological change requires inter-organisational networks to be adaptable. Through a combination of longitudinal network analysis, survey research and qualitative interviews, this project plans to study the Victorian HIV and hepatitis C sector as it responds to major advances in prevention and treatment, requiring community, health, policy and research organisations to adapt their roles and relationships. This timely and novel study aims to improve our knowledge of how to enable inter-organisational networks to adapt and improve organisational responsiveness to complex issues.Read moreRead less