Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100066
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scienti ....Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory. Enhanced modelling capacity for the Industrial Ecology Virtual Laboratory:
This project aims to enable Australian research leaders working on the integrated sustainability assessment of policies, products and projects to collaborate in the Industrial Ecology Virtual Laboratory (IELab). It seeks to develop and implement an enhanced modelling capability and suite of online analytical tools to support sustainability scientists and analysts from Australia and abroad conducting research projects of national and international significance. In particular, the project would provide policy-makers, investors and communities with detailed and tailored information to help make better decisions about a sustainable future. By upgrading IELab hardware and analytical and modelling software, the project would be versatile and flexible and remain up to date.Read moreRead less
The Forgotten Children, Ten Years On. This project aims to investigate the rippling impacts of immigration detention in the lives of people who were detained as children. Utilising an innovative arts-based, person-centred design, and in partnership with Australia’s national human rights institution and children themselves, the project aims to generate a foundational evidence-base that advances knowledge and provides the basis for improved policy and practice. Addressing the current dearth of evi ....The Forgotten Children, Ten Years On. This project aims to investigate the rippling impacts of immigration detention in the lives of people who were detained as children. Utilising an innovative arts-based, person-centred design, and in partnership with Australia’s national human rights institution and children themselves, the project aims to generate a foundational evidence-base that advances knowledge and provides the basis for improved policy and practice. Addressing the current dearth of evidence concerning the long-term impacts of childhood detention, the project will offer critical recommendations to improve services and reduce harm, while fostering increased public awareness through a high-impact radio documentary that tells the stories of Australia’s forgotten children.Read moreRead less
Engaging the over 50s to ensure the sustainability of our blood supply. Australia faces blood shortages as our population ages and demand for blood-product derived treatments increase. Donors aged over 50 donate more regularly with fewer adverse events than younger donors, yet comprise under 24% of blood donors. This multi-method project aims to investigate how those aged over 50 understand and engage with blood donation in the context of ageing, and how their involvement can be managed to maint ....Engaging the over 50s to ensure the sustainability of our blood supply. Australia faces blood shortages as our population ages and demand for blood-product derived treatments increase. Donors aged over 50 donate more regularly with fewer adverse events than younger donors, yet comprise under 24% of blood donors. This multi-method project aims to investigate how those aged over 50 understand and engage with blood donation in the context of ageing, and how their involvement can be managed to maintain psychosocial wellbeing. This project expects to generate new knowledge in recruiting, retaining, and deferring older blood donors. Expected outcomes include tailored, validated resources that may significantly benefit Australia by effectively engaging older adults to ensure the sustainability of the blood supply.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less
Oyster biomonitor for endocrine disrupting chemicals. Endocrine disrupting chemicals (EDCs) can produce alarming detrimental impacts on the reproduction and survival of aquatic species, though little is presently known in terms of their effect and impacts on sensitive marine invertebrate species. We propose the development and validation of the first marine mollusc as a biomonitor for the detection and impact assessment of estrogenic contaminants in Australian estuarine and marine waterbodies. S ....Oyster biomonitor for endocrine disrupting chemicals. Endocrine disrupting chemicals (EDCs) can produce alarming detrimental impacts on the reproduction and survival of aquatic species, though little is presently known in terms of their effect and impacts on sensitive marine invertebrate species. We propose the development and validation of the first marine mollusc as a biomonitor for the detection and impact assessment of estrogenic contaminants in Australian estuarine and marine waterbodies. Such biomonitors will provide water management agencies with the capability to manage estrogenic effluent discharges and provide the oyster industry with a tool to prevent product contamination, ensuring the continued health and sustainability of our aquatic resources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347262
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Upgrading of Wind Tunnel Research Facility with Oxford Lasers VisiSizer. Bringing together expertise within five collaborating research Centres in two Universities, an Oxford Lasers VisiSizer will be used to study the atomisation of pesticide sprays and droplet behaviour in moving flow fields. This equipment, in conjunction with the construction of a new working section in a pesticide wind tunnel research facility, will enable the simultaneous measurement of particle size and droplet velocity. T ....Upgrading of Wind Tunnel Research Facility with Oxford Lasers VisiSizer. Bringing together expertise within five collaborating research Centres in two Universities, an Oxford Lasers VisiSizer will be used to study the atomisation of pesticide sprays and droplet behaviour in moving flow fields. This equipment, in conjunction with the construction of a new working section in a pesticide wind tunnel research facility, will enable the simultaneous measurement of particle size and droplet velocity. The VisiSizer will construct images of the atomisation process and enable the interaction of spray droplets and plant canopies to be studied. Data will support modelling of pesticide transport processes and accelerate leading Australian expertise in pesticide science.Read moreRead less
Quantifying the effects of criteria air pollutants on child health - setting Australian air quality standards. The project is proposed and supported by the National Environment and Heritage Protection Council, who will be reviewing Australian air quality standards from 2005. The study aims to determine whether current air quality standards adequately protect the health of Australian school children, and to provide nationally-based information to inform any changes to the current standards. A cr ....Quantifying the effects of criteria air pollutants on child health - setting Australian air quality standards. The project is proposed and supported by the National Environment and Heritage Protection Council, who will be reviewing Australian air quality standards from 2005. The study aims to determine whether current air quality standards adequately protect the health of Australian school children, and to provide nationally-based information to inform any changes to the current standards. A cross-sectional study will examine cumulative effects; a nested panel study will quantify day-to-day effects of air pollution in sensitive children. Sampling will ensure national representation and generalisability of findings. This will be the first nationally-based study of the relationship between air quality and child health in Australia.Read moreRead less