Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Musculoskeletal Pain And Disability: Improving Outcomes Through Conservative Interventions
Funder
National Health and Medical Research Council
Funding Amount
$8,549,204.00
Summary
Musculoskeletal conditions (particularly back pain and osteoarthritis) are highly prevalent and have a major impact on health and well being of Australians. This Program aims to resolve the major priorities in the field: optimal methods to target the right treatment to the right person at the right time through our unique strategy to understand mechanisms and identify patient subgroups, and establish optimal methods to overcome barriers to translation of research to policy and practice.