Genetic Factors That Predispose Low Birth Weight Babies To Increased Risk Of Hypertension And IGT.
Funder
National Health and Medical Research Council
Funding Amount
$95,440.00
Summary
Recent research internationally has revealed that development of the fetus during pregnancy is related to later risk of hypertension and diabetes. Low birth weight infants have higher risk. While research has shown that this can't entirely be explained by genes, it is possible that some genes amplify the effect of low birth weight. This project seeks to identify such genes by examining a set of likely candidates. The targeting of these genes has been based on the knowledge that hypertension and ....Recent research internationally has revealed that development of the fetus during pregnancy is related to later risk of hypertension and diabetes. Low birth weight infants have higher risk. While research has shown that this can't entirely be explained by genes, it is possible that some genes amplify the effect of low birth weight. This project seeks to identify such genes by examining a set of likely candidates. The targeting of these genes has been based on the knowledge that hypertension and diabetes are generally more common in populations that have evolved in the tropics and have more melanin pigment in their skin. The focus in this study, therefore, is on genes that are known to be more common in these populations and also appear to affect risk of blood pressure and diabetes.Read moreRead less
A Five Year Follow-up Of People With Type 2 Diabetes & Other States Of Glucose Intolerance And Associated Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$2,677,855.00
Summary
The Australian Prospective Diabetes Study (APDS) is a 5 year follow-up study established to examine the natural history of diabetes and its complications, as well as heart disease and kidney disease. It is a follow-up to the recently completed AusDiab study and addresses some of the important gaps that exist nationally and internationally in the understanding of the burden of Type 2 diabetes and related problems. AusDiab found that 1 in 4 Australians aged 25 years and over has either diabetes or ....The Australian Prospective Diabetes Study (APDS) is a 5 year follow-up study established to examine the natural history of diabetes and its complications, as well as heart disease and kidney disease. It is a follow-up to the recently completed AusDiab study and addresses some of the important gaps that exist nationally and internationally in the understanding of the burden of Type 2 diabetes and related problems. AusDiab found that 1 in 4 Australians aged 25 years and over has either diabetes or a condition of impaired glucose metabolism (this condition is associated with substantially increased immediate risk of heart disease as well as increased risk of diabetes in the future). This new study-APDS, will be the first Australian and indeed international study of its type. We intend to invite 7000 out of the original 11,247 AusDiab sample to participate. Participants who agree to take part in the follow-up study will be involved in 2 ways: 1. A 6-12 monthly contact with participants by telephone or mail to allow reporting of changes in health and utilisation of health services. 2. A 5 year biomedical follow-up survey. This will involve a survey team travelling around Australia to test the participants for diabetes, heart and kidney disease and cardiovascular risk factors (e.g. blood pressure and cholesterol). It will accurately define how many Australians are likely to develop diabetes (as well as kidney and heart disease) in the future, and who is at highest risk. It is expected that outcomes from this study will provide crucial information for both planning and testing public health policy and for the appropriate allocation of resources including specific treatments of individuals and specific groups with or at risk of Type 2 diabetes and its complications within the Australian population.Read moreRead less
Inter-relationships Between Life-stage Transitions, Depression And Cardio-metabolic Health In Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$360,325.00
Summary
This study will investigate how social transitions and depression in young Australian adults affect the development of obesity and the adoption or persistence of behaviours that are associated with the risk of heart disease and diabetes. These behaviours include smoking, poor diet, physical inactivity and alcohol consumption. A better understanding of how psychosocial factors influence risk factors for heart disease and diabetes is needed to improve prevention strategies.