Cell survival and death are controlled by two processes known as apoptosis and autophagy. Apoptosis eliminates damaged cells whereas autophagy gets rid of faulty components in the cell. The Bcl-2 proteins regulate both processes. It is well established that dysfunctional Bcl-2 regulation leads to cancer. In this project, we aim to investigate if deregulated Bcl-2 control of autophagy also has a key role in cancer progression and to obtain a molecular picture of how this control is exerted.