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Phase III Study Of The Impact Of A Physical Activity Program On Disease-free Survival For Early Colon Cancer
Funder
National Health and Medical Research Council
Funding Amount
$2,556,385.00
Summary
There is clear evidence that physical activity can reduce the risk of developing bowel cancer and some evidence suggesting it may decrease the risk of a recurrence of bowel cancer. This study will provide reliable evidence as to whether people who participate in a structured physical activity programme after treatment for stage II or III colorectal cancer can increase their likelihood of being alive without a cancer recurrence at three years, compared to those who have standard follow-up.
Molecular Mechanism And Novel Activators Of Amino Acid And Calcium-sensing Class 3 G-protein Coupled Receptors
Funder
National Health and Medical Research Council
Funding Amount
$519,715.00
Summary
When we eat protein-containing foods, our bodies extract twenty different amino acids for growth and tissue regeneration. Broad-spectrum amino acid sensing receptors detect the increases in blood amino acid levels and respond by triggering the release of biochemical signals. This project will establish the molecular rules by which these receptors work and identify novel activators with potential therapeutic application for the control of growth, tissue regeneration and calcium metabolism.
The Prognostic Significance Of Obesity In Joint Arthroplasty
Funder
National Health and Medical Research Council
Funding Amount
$57,803.00
Summary
There are over 55,000 hip and knee joint replacements performed in Australia every year and the number is rising. The incidence of obesity is also rising. Higher risk of surgical complications following joint replacement surgery has been reported in obese patients. It is therefore imperative that we determine the impact obesity has on the outcome of joint replacement surgery in order to determine if treatment needs to be modified.
Certain Death In Uncertain Time: A Qualitative Study Of The Experience Of Advanced Ovarian Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$221,755.00
Summary
Modern medicine aims to find effective treatments for life-threatening diseases. Cures are seldom found, however. More typically, rapidly fatal diseases gradually become less rapidly fatal. Consequently, there is a category of patients who are certain they will die from their disease or a related factor, but who are equally uncertain as to whether they have weeks or years left to live. It is difficult to discuss this predicament because we do not even have a name for it, let alone a useful termi ....Modern medicine aims to find effective treatments for life-threatening diseases. Cures are seldom found, however. More typically, rapidly fatal diseases gradually become less rapidly fatal. Consequently, there is a category of patients who are certain they will die from their disease or a related factor, but who are equally uncertain as to whether they have weeks or years left to live. It is difficult to discuss this predicament because we do not even have a name for it, let alone a useful terminology to describe it. The absence of discussion exacerbates patients' social isolation. Also, the quality of their remaining life, and the quality of the care they get, depends heavily on the quality of understanding and communication within the social systems that support them. A growing proportion of patients in developed countries fall into this category, including the 1200 Australian women who are diagnosed each year with advanced ovarian cancer. This study aims to increase our understanding of the experience of certain death in uncertain time by recruiting a group of 20 women with advanced ovarian cancer, and interviewing them every few months over three years. The study will explore all aspects of the experience of having advanced ovarian cancer, and generate a terminology for it - one that grows out of the women's own language. The study will inform the organisation and delivery of clinical care and services to women with ovarian cancer. It will also inform patient education programs, and help to tune medical education to the particular needs and perceptions of patients who are experiencing the certainty of death in uncertain time. Finally, the researchers will also explore the implications of the findings for medical ethics and health law, and for communication, information and decision-making in cancer medicine.Read moreRead less
Improving Outcomes For Children With Emotional And Behavioural Difficulties Through A School-based Intervention: A Pilot Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$88,662.00
Summary
Over 50% of adult mental illness begins during childhood. Our health system is under increasing strain to support such children, especially public services. Teachers are in an ideal position to detect emerging issues and organise intervention, but they need help. This project aims to explore the potential for a collaboration between health and education to identify children with emotional and behavioural difficulties sooner and more accurately, and put in place effective strategies of support.
Improving School Transition By Improving Child Sleep: A Translational Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$745,827.00
Summary
A successful transition to school sets a child on a path for life. A poor transition can lead to early drop out, poor peer relationships and poor emotional skills. In 2008/09, we found that a brief sleep intervention for children improved key determinants of a successful transition including social-emotional functioning and parent mental health. We now plan to see if the same intervention, delivered by school nurses, can have a similar effect.
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.