Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a ....Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a-chip systems, to give engineers and scientists design rules for this new technology, opening the way to new products that will improve our everyday lives. One immediate product to be researched is 'precision' double emulsions, which show unique properties for the delivery of chemotherapy medicines.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Nanostructured Degradable Polymer for Drug Delivery. The success of synthesising nanostructured degradable polymers will position Australia at the world forefront in the field of nanotechnology, bioengineering and healthcare sectors in both fundamental and applied research. This multi-disciplinary research has the potential to generate patentable technologies with economic benefits to Australia. The project also involves fundamental research into surface chemistry, nanostructure, polymer science ....Nanostructured Degradable Polymer for Drug Delivery. The success of synthesising nanostructured degradable polymers will position Australia at the world forefront in the field of nanotechnology, bioengineering and healthcare sectors in both fundamental and applied research. This multi-disciplinary research has the potential to generate patentable technologies with economic benefits to Australia. The project also involves fundamental research into surface chemistry, nanostructure, polymer sciences and will be a meaningful contribution to the advancement of scientific knowledge in Australia. All these will enhance the international competitive profile of Australia in the field of nanotechnology for drug delivery.Read moreRead less
Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performi ....Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the r ....Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the receptor-ligand interactions using inexpensive miniature spectrometers - radically transforming these assays. This would generate fundamental and applied knowledge of materials sciences, photonic, and biointerfaces for label-free, ultra-sensitive, and selective assays to enable future drug and diagnostics target discovery. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0667994
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
National Nanolithography Facility. Nanotechnology is expected to have a major impact on quality of life and global economy. It is predicted to generate revenues as big as the ICT sector in 20 years time. The National Nanolithography Facility will enhance the Australian capability in the field of nanoscale science and technology. This will enable Australian researchers to achieve major impacts in many areas of nanotechnology with a strong potential impact on industry sectors such as computers, ....National Nanolithography Facility. Nanotechnology is expected to have a major impact on quality of life and global economy. It is predicted to generate revenues as big as the ICT sector in 20 years time. The National Nanolithography Facility will enhance the Australian capability in the field of nanoscale science and technology. This will enable Australian researchers to achieve major impacts in many areas of nanotechnology with a strong potential impact on industry sectors such as computers, communications, defence, health, bio-security. This facility has the potential for developing new technologies of fundamental as well as applied interest.Read moreRead less
Experimental and theoretical study of the formation of nanomaterials under reduced gravity conditions. This work will investigate the formation of nanomaterials and model this process to provide the skills to develop better nanocomposite materials. A better understanding of the process and the effect gravity has on it provides better control of this industrially significant process allowing enhanced process optimisation and product design. The results are directly relevant to many organisations ....Experimental and theoretical study of the formation of nanomaterials under reduced gravity conditions. This work will investigate the formation of nanomaterials and model this process to provide the skills to develop better nanocomposite materials. A better understanding of the process and the effect gravity has on it provides better control of this industrially significant process allowing enhanced process optimisation and product design. The results are directly relevant to many organisations currently studying nanomaterials. The work provides important results in a frontier technologies which will help the building and transforming of Australian industries with applications in energy conversion, water purification, quantum semi-conductors, optical materials, films for material separation and fuel cells.Read moreRead less
A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and ....A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.Read moreRead less