Precision low energy experiments to search for new physics. This project aims to give experimental answers to long existing theoretical questions about the origins and nature of dark matter. Dark matter is a fundamental component of the universe, yet the nature of its composition is still unknown. There is growing evidence that dark matter is comprised of low mass and weakly interacting particles. By developing ultra-precise measurement tools and new techniques, this project aims to perform a st ....Precision low energy experiments to search for new physics. This project aims to give experimental answers to long existing theoretical questions about the origins and nature of dark matter. Dark matter is a fundamental component of the universe, yet the nature of its composition is still unknown. There is growing evidence that dark matter is comprised of low mass and weakly interacting particles. By developing ultra-precise measurement tools and new techniques, this project aims to perform a stringent and comprehensive new laboratory search for ultra-light dark matter particles, over likely mass ranges not yet searched. The knowledge gained will provide economic benefits through commercialisation and stimulation of new research and development, and to defence through applications in radar, communications and sensing.Read moreRead less
Development of a prime-boost anti-cancer vaccine. New vaccination strategies are urgently needed for a variety of diseases, including cancer. The problem with cancer vaccines is that it is difficult to trigger a response to a self protein. We propose that a prime-boost vaccination, using yellow fever virus and modified vaccinia virus ankara, could create very strong responses against tumor antigens. This approach can be patented and can revive that field of tumor vaccination, which is currently ....Development of a prime-boost anti-cancer vaccine. New vaccination strategies are urgently needed for a variety of diseases, including cancer. The problem with cancer vaccines is that it is difficult to trigger a response to a self protein. We propose that a prime-boost vaccination, using yellow fever virus and modified vaccinia virus ankara, could create very strong responses against tumor antigens. This approach can be patented and can revive that field of tumor vaccination, which is currently restrained by the difficulty of breaking immunological tolerance. We envisage the construction of a anti-cancer vaccine vector with obvious market potential. An exciting prospect is that this approach could be used as a prophylactic vaccine and possibly also as a therapeutic vaccine.Read moreRead less
Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased c ....Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased cellular energy production can be harnessed to make valuable biological products, with unprecedented efficiency.Read moreRead less
Kadare post Communism: Albania, the Balkans and Europe in the Work of Ismail Kadare, 1990-2008. Albanians make up a small but important segment of multicultural Australia. Through the work of Albania's greatest writer and intellectual, Ismail Kadare, we can come to a better understanding of Albanians, their history and culture, and hence of Australia as a multicultural entity. Moreover traditionally Islamic Albania, with its Ottoman history and culture, is seeking inclusion into the European Uni ....Kadare post Communism: Albania, the Balkans and Europe in the Work of Ismail Kadare, 1990-2008. Albanians make up a small but important segment of multicultural Australia. Through the work of Albania's greatest writer and intellectual, Ismail Kadare, we can come to a better understanding of Albanians, their history and culture, and hence of Australia as a multicultural entity. Moreover traditionally Islamic Albania, with its Ottoman history and culture, is seeking inclusion into the European Union, Australia's major partner in trade, tourism, education and culture. Kadare's post-communist works on the subjects of Europe, Islam, Muslims and the West, and Balkan politics and history provide a valuable lesson on the interrelationships of politics, culture and patriotism in a global context for contemporary Australia.Read moreRead less
The roles and regulators of new plant cells linked to root transport. Plant genomics has moved to the single cell resolution, allowing precise investigations of previously hidden cell types and cell states that respond to environmental stress and that vary among differentially adapted plant populations. Here, we will extend our pioneering efforts that have mapped and discovered novel root cell types, to determine their salt and nutrient stress responses, and to elegantly dissect the underling ca ....The roles and regulators of new plant cells linked to root transport. Plant genomics has moved to the single cell resolution, allowing precise investigations of previously hidden cell types and cell states that respond to environmental stress and that vary among differentially adapted plant populations. Here, we will extend our pioneering efforts that have mapped and discovered novel root cell types, to determine their salt and nutrient stress responses, and to elegantly dissect the underling causal genetic variation. The unique cell markers and regulatory networks will be validated with tissue specific and transgenic tools that can work across a host of plant species to reveal adaptive cellular responses to harsh environmental conditions.Read moreRead less
Rapid structural condition assessment using adaptive model updating. The proposed project has potential to significantly enhance the accuracy with which the condition (and hence load bearing capacity) of existing infrastructure can be determined. By providing a technique of model updating that can be applied effectively in real time, location of damage will be able to be determined accurately. Economic benefits will be reaped, both through saving infrastructure from demolition where the conditio ....Rapid structural condition assessment using adaptive model updating. The proposed project has potential to significantly enhance the accuracy with which the condition (and hence load bearing capacity) of existing infrastructure can be determined. By providing a technique of model updating that can be applied effectively in real time, location of damage will be able to be determined accurately. Economic benefits will be reaped, both through saving infrastructure from demolition where the condition is found to be adequate, and by replacing or repairing inadequate structures before costly failure occurs. This is particularly important as much of Australia's infrastructure is aging, and unnecessary periodic replacement of infrastructure is not sustainable.Read moreRead less
Blast Damage and Fragmentation Prediction for Occupants and Structure Protection. Protecting infrastructures against blast loads from terrorist bombing or accidental explosion is a challenge. Researchers have been working on developing a numerical model, but the progress is slow owing to difficulties in modelling nonlinear and high strain rate damage process. Most blast effect assessment is based on empirical relations from blast tests. These have been demonstrated not necessarily yielding accur ....Blast Damage and Fragmentation Prediction for Occupants and Structure Protection. Protecting infrastructures against blast loads from terrorist bombing or accidental explosion is a challenge. Researchers have been working on developing a numerical model, but the progress is slow owing to difficulties in modelling nonlinear and high strain rate damage process. Most blast effect assessment is based on empirical relations from blast tests. These have been demonstrated not necessarily yielding accurate prediction owing to variations of structural properties from the test model. A reliable numerical model is therefore important. It will result in big savings from blast tests, and better prediction of blast effects for structure and occupant protection. It will have applications in civil, mining and defence engineering. Read moreRead less
NUMERICAL ANALYSIS OF DYNAMIC REPONSE AND DAMAGE OF FRAME STRUCTURES TO EXPLOSIVE LOADS. Understanding structural response to explosive loads is essential to protect critical infrastructure against terrorist bombing or industrial explosions. Current practice in analysis and design of structures to withstand explosive loads uses either empirical methods or a simplified structure model. In many cases, engineers need to know the structure response in more detail in order to protect the structure an ....NUMERICAL ANALYSIS OF DYNAMIC REPONSE AND DAMAGE OF FRAME STRUCTURES TO EXPLOSIVE LOADS. Understanding structural response to explosive loads is essential to protect critical infrastructure against terrorist bombing or industrial explosions. Current practice in analysis and design of structures to withstand explosive loads uses either empirical methods or a simplified structure model. In many cases, engineers need to know the structure response in more detail in order to protect the structure and plan evacuation procedures. This project will study the response and damage mechanism of structures to explosive loads, and develop a numerical model to predict structural response and damage. It will have immediate and wide-ranging applications in defence, construction and mining engineering.Read moreRead less
Experimental and numerical study of dynamic properties of concrete and fibre reinforced concrete materials. Recent disastrous examples of life and economy loss due to terrorist action or accident explosion include Bali bombing and Western Australia gas explosion. Reliable prediction of structure response to blast and impact loads is essential for life and economy protection against such loads. This project will perform laboratory tests and numerical simulations to study the construction material ....Experimental and numerical study of dynamic properties of concrete and fibre reinforced concrete materials. Recent disastrous examples of life and economy loss due to terrorist action or accident explosion include Bali bombing and Western Australia gas explosion. Reliable prediction of structure response to blast and impact loads is essential for life and economy protection against such loads. This project will perform laboratory tests and numerical simulations to study the construction material properties under dynamic loading conditions, and develop numerical models for accurate predictions of structure response to blast loads. The project contributes to the integrated effort for a secure Australia. It will result in enormous savings from conducting blast tests and will have applications in civil, mining and defence engineering.Read moreRead less
Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the devel ....Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the development of scale-up protocol for PI based methodologies, with particular emphasis on the production of biomaterials. GXLs technology is frontier technology with regard to the biomaterials sector.Read moreRead less