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Cellular And Molecular Determinants That Regulate Osteoblasts At The Endosteal Niche During HSC Mobilisation
Funder
National Health and Medical Research Council
Funding Amount
$178,523.00
Summary
Treatments for leukaemia (e.g. chemotherapy) severely deplete immune and blood cells from patients. Transplantation of new blood forming cells (blood stem cells) into these patients is essential, but challenges are faced with isolating sufficient numbers in ways that preserve their ability to reconstitute the blood post transplant. My research aims to advance understanding of current methods used to isolate these cells and ultimately to improve the success of blood stem cell transplantation.
Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will p ....Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will place increasing demands on young people with disabilities. Innovative approaches are desperately. Such programming must begin early, by including children in an age-appropriate ways and simultaneously addressing the issues of adults who have the most significant influence: parents and teachers.Read moreRead less
From causative genes to establishing therapies for patients with neuromuscular diseases. A major focus of this project will be pursuing multiple therapeutic approaches for a class of skeletal muscle diseases, which are most often severe and lethal within the first year of life. It will also hunt down the defective genes in human patients with other neuromuscular diseases and explore how these cause disease.
Implementing and evaluating the impact of the Carer Support Needs Assessment Tool (CSNAT) in community palliative care. The support needs of family caregivers at end of life will be assessed using a comprehensive tool and addressed by service providers to improve carers' psychological and physical wellbeing, carer burden, bereavement outcomes and the likelihood of the patient achieving their preferred place of death.
A phenomenological approach to improve radioembolisation treatment of cancer. In recent years, radioembolisation for liver cancer has become an effective therapeutic option. However, it is likely that patients are being “under-treated” as doses remain based on results from external radiation therapy. This project will develop a phenomenological approach to radionuclide therapy to improve outcomes for cancer patients.
Antiviral compounds to inhibit the replicase of hepatitis C virus. Hepatitis C virus is a major public health problem. There are currently 200,000 infected individuals in Australia and 16,000 new infections every year. There is no specific treatment and current therapy treats a small percentage of patients only, which consists of interferon-alpha and ribavirin. This results in side effects and only a 50% cure rate. This study's outcomes are expected to lead to greater access to treatment and imp ....Antiviral compounds to inhibit the replicase of hepatitis C virus. Hepatitis C virus is a major public health problem. There are currently 200,000 infected individuals in Australia and 16,000 new infections every year. There is no specific treatment and current therapy treats a small percentage of patients only, which consists of interferon-alpha and ribavirin. This results in side effects and only a 50% cure rate. This study's outcomes are expected to lead to greater access to treatment and improved therapy resulting in higher cure rates and in a dramatic reduction in the cost of treating patients. A novel therapy will provide considerable benefits for the national biotechnology industry.Read moreRead less
Screening platforms for malaria drug discovery: identification of new therapeutics. Innovative image based technologies will be developed to identify molecules which stop malaria parasite growth and its transmission to the mosquito host. As more resistance is emerging against the current drugs of choice, new molecules acting through different mechanisms are urgently needed.
New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen ....New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen the expertise in biomedical engineering and instrumentation development in Australia, where we have international leadership. The technologies developed will provide advanced tools for making fundamental biological discoveries and translating them into biotechnological or clinical applications.Read moreRead less
Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and compu ....Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and computational algorithms that enable microPET to non-invasively image the brains of conscious, freely moving animals while simultaneously observing their behaviour. These new technologies will, for the first time, allow neuroscientists to study the genetic, behavioural and neurochemical correlates of brain disease.Read moreRead less
Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language ....Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language disorder and to establish whether variations in the speech and language regions of the brain found in adult stuttering research are also present in children who stutter, and to explore the possibility that different variations in brain activation and/or morphology may predict persistence and recovery.
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