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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100156
Funder
Australian Research Council
Funding Amount
$289,500.00
Summary
3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-ti ....3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-tissue interfaces), biomedical devices (implantable devices and drug-delivery systems), nanofluidics, and photonic crystals. In each of these fields, we will use GT2 to print variety of polymers, hydrogels, metals and ceramics, for example by printing polymer-derived nanoceramics that will be simultaneously strong and tough.Read moreRead less
Designer nano-carriers for targeted hydrophobic anticancer drug delivery with enhanced bioavailability. This project will prepare novel nano-carriers for water insoluble anticancer drug delivery with enhanced bioavailability and targeted therapy. The techniques developed in this project will advance the intellectual leadership of Australia and improve therapeutic efficacy, reduce side effects, and promote good health.
Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interf ....Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interfaces. New fundamental discoveries will have an impact on technologies such as medical device coatings, biomaterials, biosensors, microfluidics devices, protein purification and diagnostics assays that are critically dependent on the biological function of adsorbed or immobilized proteins.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100140
Funder
Australian Research Council
Funding Amount
$1,050,000.00
Summary
A multiple ion beam facility for microscopy and nanofabrication. This project aims to establish a powerful multiple ion beam system for nanoscience research. The demand for customised therapies, secure communication and efficient energy harvesting prompts the development of nanoscale devices that can interface and interact with the environment: nanotechnology systems with fully functional sensors, detectors, energy and data processing modules. This project would increase the ability to observe a ....A multiple ion beam facility for microscopy and nanofabrication. This project aims to establish a powerful multiple ion beam system for nanoscience research. The demand for customised therapies, secure communication and efficient energy harvesting prompts the development of nanoscale devices that can interface and interact with the environment: nanotechnology systems with fully functional sensors, detectors, energy and data processing modules. This project would increase the ability to observe and manipulate the structure of materials at the nanometre length-scale. This project is expected to boost Australia’s research capacity in nanoscience and develop materials for nanoelectronics, energy and the environment, and structural materials. These outcomes will benefit Australia’s capacity to develop advanced manufacturing industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100985
Funder
Australian Research Council
Funding Amount
$427,116.00
Summary
Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous syst ....Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous system in different situations and the study of how this affects neural function. This is expected to provide significant benefits, enabling the development of regulatory frameworks that ensure the safe implementation of new therapies for neurological and neurodegenerative disorders.Read moreRead less
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100143
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
High sensitivity superconducting quantum interference device vibrating sample magnetometer. A highly sensitive magnetometer will be used in research projects covering nanotechnology, biomedicine, engineering, and mineral resources to elucidate the structure and composition of materials and fluids. The instrument is so sensitive it can measure the magnetic properties of materials that are normally considered non-magnetic such as blood.
Safe and efficient biomedical nanomaterials. This project aims to rationally engineer nanomaterials with controlled biological responses. Nanomaterials are becoming widespread in biomedicine and engineering, but are inefficient and unsafe. This project will develop atomic scale models to understand interactions between engineered nanoparticles and the crowded cellular environment. It will design extremely sensitive biosensors and theranostic nanodevices combining medical imaging capacity with pr ....Safe and efficient biomedical nanomaterials. This project aims to rationally engineer nanomaterials with controlled biological responses. Nanomaterials are becoming widespread in biomedicine and engineering, but are inefficient and unsafe. This project will develop atomic scale models to understand interactions between engineered nanoparticles and the crowded cellular environment. It will design extremely sensitive biosensors and theranostic nanodevices combining medical imaging capacity with precision targeted drug delivery to improve efficiency and safety of nanomaterials for biomedical applications in both vitro and in vivo enabling cost effective early diagnostics and more efficient treatments.Read moreRead less
Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices. Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowle ....Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices. Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowledge of the molecular mechanisms of nanomaterials interactions with molecular components of biological environment which will be exploited to improve molecular recognition needed in biosensors and drug delivery applications. The project outcomes will help formulate rational design principles for efficient biomedical materials and nanodevices.Read moreRead less
Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to ....Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to develop blood pressure correlation algorithms and evaluate sensing performances. New knowledge and commercial technologies will make Australian medical technology industries competitive global leaders in wearable technology industries.Read moreRead less